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Possible Interaction: Cyclosporine and St John's Wort

Research Papers that Mention the Interaction

CONCLUSION HYF content of SJW extracts significantly affects the extent of the pharmacokinetic interaction between CSA and SJW.
CONCLUSION HYF content of SJW extracts significantly affects the extent of the pharmacokinetic interaction between CSA and SJW.
In addition, a 65% (95% CI, 53% to 85%; P < .05) increase in daily CSA doses was required during high-HYF SJW treatment.
The dose-corrected AUC 0-12 for CSA (monoclonal) decreased significantly compared with baseline by 52% (95% CI, -46% to -56%; P < .05) after 2 weeks of comedication with high-HYF SJW.
Clinical pharmacology and therapeutics  •  2004  |  View Paper
Additionally, the metabolite pattern of CSA was substantially altered during SJW treatment.
CONCLUSION Administration of SJW extract to patients receiving CSA treatment resulted in a rapid and significant reduction of plasma CSA concentrations.
CONCLUSION Administration of SJW extract to patients receiving CSA treatment resulted in a rapid and significant reduction of plasma CSA concentrations.
RESULTS After … weeks of SJW coadministration, dose-corrected AUC0-12, Cmax and Ctrough values for CSA decreased significantly by 46%[geometric mean ratio baseline/SJW (95% CI): 1.83 (1.63-2.05)], 42%[1.72 (1.42-2.08)], and 41%[1.70 (1.17-2.47)], respectively.
RESULTS After … weeks of SJW coadministration, dose-corrected AUC0-12, Cmax and Ctrough values for CSA decreased significantly by 46%[geometric mean ratio baseline/SJW (95% CI): 1.83 (1.63-2.05)], 42%[1.72 (1.42-2.08)], and 41%[1.70 (1.17-2.47)], respectively.
British journal of clinical pharmacology  •  2003  |  View Paper
St. John's wort , a popular over-the-counter drug for treatment of depression, might reduce concentrations of drugs such as cyclosporin and indinavir and lead to drug resistance and treatment failure.
Pharmacopsychiatry  •  2003  |  View Paper
Co-administration with SJW has resulted in significant reductions in trough plasma concentrations of indinavir and cyclosporin [1, 2].
British journal of clinical pharmacology  •  2002  |  View Paper
BACKGROUND Many commonly ingested substances such as grapefruit juice and Hypericum perforatum (St John's wort) have been found to interact with important therapeutic agents such as cyclosporine (INN, ciclosporin).
Clinical pharmacology and therapeutics  •  2001  |  View Paper
For example, St John's wort significantly reduced the area under the plasma concentration-time curve (AUC) and blood concentrations of cyclosporine , midazolam, tacrolimus, amitriptyline, digoxin, indinavir, warfarin, phenprocoumon and theophylline.
Current drug metabolism  •  2012  |  View Paper
Some herbal products (e.g. St. John's wort ) have been shown to lower the plasma concentration (and/or the pharmacological effect) of a number of conventional drugs including cyclosporine , indinavir, irinotecan, nevirapine, oral contraceptives and digoxin.
African journal of traditional, complementary, and alternative medicines : AJTCAM  •  2011  |  View Paper
CONCLUSION Despite the potential for a serious drug-herb interaction involving St. John's wort and cyclosporine , less than half of the pharmacists and natural health product retailers that were encountered in the study addressed this topic with the prospective patient/client.
CONCLUSION Despite the potential for a serious drug-herb interaction involving St. John's wort and cyclosporine , less than half of the pharmacists and natural health product retailers that were encountered in the study addressed this topic with the prospective patient/client.
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique  •  2010  |  View Paper
Case reports or case series suggest interactions of St John’s wort with adrenergic vasopressors, anaesthetics, bupropion, buspirone, ciclosporin , eletriptan, loperamide, nefazodone, nevirapine, oral contraceptives, paroxetine, phenprocoumon, prednisone, sertraline, tacrolimus, theophylline, tibolone, tryptophan, venlafaxine and warfarin.
Clinical … St John’s wort (Hypericum perforatum), via cytochrome P450 (CYP) and/or P-glycoprotein induction, … concentrations (and/or increases the clearance) of alprazolam, amitriptyline, atorvastatin, chlorzoxazone, ciclosporin , debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide, imatinib, indinavir, irinotecan, ivabradine, mephenytoin, methadone, …, oral contraceptives, quazepam, simvastatin, tacrolimus, talinolol, verapamil, voriconazole and warfarin.
Drugs  •  2009  |  View Paper
Significantly reduced concentrations of various therapeutic drugs such as digoxin, theophylline, cyclosporine , tacrolimus, tricyclic antidepressants, warfarin, and protease inhibitors can be observed due to interaction of these drugs with St. John's wort , causing treatment failure.
Therapeutic drug monitoring  •  2008  |  View Paper
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