Possible Interaction: Cyclosporine and Resveratrol

“The levels of IL-2 and INF-gamma in lymphocyte culture supernatant reduced markedly (P<0.05), on condition that the concentration of resveratrol was over 5 mg/L. The combination of more than 2.5 mg/L of resveratrol with cyclosporine A had synergism.”

“Resveratrol upregulated expression of the CaN, NFATc1, and Runx2 genes at both mRNA and protein levels compared to the control group (p < 0.05), while CsA reduced the effects of resveratrol (p < 0.05).”

“However, CIN was more effective than RES , their combination showed a positive synergistic effect in protecting the cells against oxidative injury caused by CYA.”

“Concurrent treatment with RSVL (10(-6) mol l(-1)) significantly reversed the CsA (3 x 10(-6) mol l(-1))-mediated decrease in NO production and restored the proliferation and differentiation potential of BMSCs.”

“Our data suggest that (1) the NO/cGMP pathway may play an important role in both RSVL-induced and CsA-inhibited proliferation and osteoblastic differentiation of mouse BMSCs, and (2) RSVL may act through an ER/NO/cGMP pathway to reverse the inhibitory effect of CsA on BMSC cultures.”

“Both hydroxytyrosol and resveratrol strengthened the CsA induction of HO-1 expression.”

“Both hydroxytyrosol and resveratrol strengthened the CsA induction of HO-1 expression.”

“Increased CyA concentration has been reported in patients with grapefruit juice, chamomile, or berberine, and with cannabidiol or resveratrol in animal studies.”

“We found a significant inhibition of human CYP3A4-dependent transformation of cyclosporine by resveratrol , with IC50 = 4.5 microM. We studied the kinetics parameters of CYP3A4 transformation of resveratrol and structurally related, naturally occurring stilbenes.”