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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Quinine
Research Papers that Mention the Interaction
“Results showed a gradual decrease in the cyclosporine A level from a baseline value of 328 ng/ml to 107 ng/ml after seven days of oral quinine with a subsequent rise to pre-treatment level after discontinuation of quinine.”
“These findings suggest an in vivo drug interaction between cyclosporine A and quinine.”
“We report a previously undocumented drug interaction between cyclosporine A and quinine.”
Drug interaction between cyclosporine A and quinine in a renal transplant patient with malaria.“Patients taking cyclosporine were at risk for pharmacokinetic drug interactions when cyclosporine was used in combination with sertraline, losartan, valsartan, quinine , atorvastatin, simvastatin, pravastatin, fluvastatin, alendronate, digoxin, acyclovir, and oxycodone.”
“Synergistic interaction between Quin and DPM or Tam was greater than that between Quin and CsA. Quin combined with CsA increased intracellular DNR accumulation significantly as compared with either of them alone.”
“ Cyclosporine A (50 mg/kg), erythromycine (40 mg/kg), … mg/kg) increased the brain-to-plasma quinine concentration ratio (by factors of 3.8-, 1.8-, 1.9- and 2.5-fold, respectively) … ratio in plasma (by factors 2.1-, 3.7-, 1.8- and 2.0-fold, respectively).”
Increased uptake of quinine into the brain by inhibition of P-glycoprotein.“Furthermore, we found synergistic antimalarial interactions between cyclosporin A and quinine , mefloquine or halofantrine and antagonism between cyclosporin A and chloroquine.”
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