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Last Updated: 3 years ago

Possible Interaction: Cyclosporine and Quercetin

supplement:

Quercetin

Research Papers that Mention the Interaction

In conclusion, quercetin and rutin decreased the bioavailability of CSP through activating P-gp and CYP3A.
The results showed that quercetin and rutin significantly decreased the C(max) of CSP by 67.8 and 63.2% and reduced the AUC(0-540) by 43.3 and 57.2%, respectively.
Transplant patients treated with Neoral should avoid concurrent consumption of quercetin or rutin to minimize the risk of allograft rejection.
Journal of agricultural and food chemistry  •  2011  |  View Paper
The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein, genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (Pe) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin, across Caco-2 and MDCKII-MDR1 cell transport models.
Xenobiotica; the fate of foreign compounds in biological systems  •  2006  |  View Paper
The OATP1A2-, OATP2B1-, and OCT1-mediated quercetin uptake was inhibited by known inhibitors such as naringin, cyclosporin A , and quinidine, respectively.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2014  |  View Paper
The present study identified a novel flavonoid-drug interaction, which may have implications for patients taking CsA and quercetin supplements or on a quercetin-containing diet.
Molecular medicine reports  •  2018  |  View Paper
Co-administration of Que (25,50 and 100 mg/kg) decreased the maximum serum concentration of CsA by 46, 50 and 47% in a dose-independent manner.
It was demonstrated that Que was able to reduce the bioavailability of CsA following multiple concomitant doses in rats.
Molecular medicine reports  •  2016  |  View Paper
Co-administration of the quercetin , telmisartan and cyclosporine A significantly increased the area under the curve and peak plasma concentration of clopidogrel carboxylic acid in rats.
Archives of pharmacal research  •  2012  |  View Paper
Our previous study reported that quercetin significantly decreased the bioavailability of cyclosporin , a substrate for CYP3A4 and Pgp, in rats and pigs.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2006  |  View Paper
It is suggested that concurrent use of quercetin or quercetin-containing dietary supplement or herbs with cyclosporin or other medications whose absorption and metabolism are mediated by Pgp and/or CYP3A4 should require close monitoring.
quercetin … cyclosporin AUC(0-3) (area under the concentration-time curve from time zero to 3 h) by 56% and AUC(0-t) (area under the … zero to the last point) by 43% in pigs and rats, respectively, indicating that the coadministration of quercetin significantly decreased cyclosporin oral bioavailability.
Life sciences  •  2002  |  View Paper
It is likely that quercetin , due to its antioxidant properties, prevented CsA-induced ROS and consequently CsA nephrotoxicity.
Methods and findings in experimental and clinical pharmacology  •  2001  |  View Paper