Possible Interaction: Cyclosporine and Quercetin

“In conclusion, quercetin and rutin decreased the bioavailability of CSP through activating P-gp and CYP3A.”

“The results showed that quercetin and rutin significantly decreased the C(max) of CSP by 67.8 and 63.2% and reduced the AUC(0-540) by 43.3 and 57.2%, respectively.”

“Transplant patients treated with Neoral should avoid concurrent consumption of quercetin or rutin to minimize the risk of allograft rejection.”

“The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein, genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (Pe) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin, across Caco-2 and MDCKII-MDR1 cell transport models.”

“The OATP1A2-, OATP2B1-, and OCT1-mediated quercetin uptake was inhibited by known inhibitors such as naringin, cyclosporin A , and quinidine, respectively.”

“The present study identified a novel flavonoid-drug interaction, which may have implications for patients taking CsA and quercetin supplements or on a quercetin-containing diet.”

“Co-administration of Que (25,50 and 100 mg/kg) decreased the maximum serum concentration of CsA by 46, 50 and 47% in a dose-independent manner.”

“It was demonstrated that Que was able to reduce the bioavailability of CsA following multiple concomitant doses in rats.”

“Co-administration of the quercetin , telmisartan and cyclosporine A significantly increased the area under the curve and peak plasma concentration of clopidogrel carboxylic acid in rats.”

“Our previous study reported that quercetin significantly decreased the bioavailability of cyclosporin , a substrate for CYP3A4 and Pgp, in rats and pigs.”

“It is suggested that concurrent use of quercetin or quercetin-containing dietary supplement or herbs with cyclosporin or other medications whose absorption and metabolism are mediated by Pgp and/or CYP3A4 should require close monitoring.”

“… quercetin … cyclosporin AUC(0-3) (area under the concentration-time curve from time zero to 3 h) by 56% and AUC(0-t) (area under the … zero to the last point) by 43% in pigs and rats, respectively, indicating that the coadministration of quercetin significantly decreased cyclosporin oral bioavailability.”

“It is likely that quercetin , due to its antioxidant properties, prevented CsA-induced ROS and consequently CsA nephrotoxicity.”