Possible Interaction: Cyclosporine and Potassium

“Mean serum concentrations of potassium at these dates were significantly higher in cyclosporine-treated patients than azathioprine-treated patients.”

“We speculate that an idiosyncratic response to CyA resulted in pseudohypoaldosteronism and produced a defect in potassium secretion.”

“Drug therapy including cyclosporin A , enalapril, atenolol, phenytoin, necessary to control active disease and severe hypertension contributed to elevated potassium levels.”

“Incubation with cyclosporine did not alter the resting tone of the vessels, but decreased the maximum contractile response and the sensitivity of the vessels to stimulation with exogenous noradrenaline and potassium.”

“ CsA resulted in an increase in BUN and serum K+, along with a decrease in creatinine clearance, fractional excretion of potassium , and renal cortical Na+, K+ -ATPase activity, as compared with oil vehicle administration.”

“Similarly, in vitro CsA (8.3 X 10(-8) to 8.3 X 10(-6) M) augmented in a concentration-dependent manner both the sensitivity and the maximum response to NE and potassium.”

“ CsA , administered daily by gavage at 50 mg/kg body weight, produced a nephrotoxicity which was characterized by reductions in the clearance rates of creatinine, sodium and potassium , and increased glycosuria, enzymuria and urine flow rate.”