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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Polyunsaturated Fatty Acids
Research Papers that Mention the Interaction
“In fact, CsA inhibited, in a concentration‐dependent manner, the activation of lysophosphatid acyltransferase‐catalyzed elevated incorporation of cis‐polyunsaturated fatty acids into plasma membrane phospholipids.”
Cyclosporin A inhibits T cell receptor‐induced interleukin‐2 synthesis of human T lymphocytes by selectively preventing a transmembrane signal transduction pathway leading to sustained activation of a protein kinase C isoenzyme, protein kinase C‐β“The mean value of PUFA n-3 was significantly higher in the CsA group compared with the Tac group (P < .015) and control (P < .002) as well as in the Tac group compared with control (P < .001).”
“In conclusion, CsA and SRL modulated the biosynthesis of polyunsaturated FAs, decreasing Delta9 desaturase and increasing Delta6 and Delta5 desaturase activities.”
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