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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Peppermint Oil
Research Papers that Mention the Interaction
“ Peppermint oil (… cyclosporine maximum concentration (C(max)) from 0.60 to 1.6 microg/mL and increased the area under the concentration versus time curve (AUC(0-…(max)) was increased from 2 to 6 h. Terminal half-life (10 h) and mean residence time (MRT; 15 h) were unaffected.”
“ Peppermint oil inhibits cyclosporine metabolism in vitro.”
“The lack of a significant ketoconazole effect may reflect poor metabolism of cyclosporine in rat intestinal tissue and suggests that inhibition of cytochrome P450 3A is not the only means by which peppermint oil enhances cyclosporine oral bioavailability.”
Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole.
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