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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Cyclosporine and Palmitic Acid

Research Papers that Mention the Interaction

Further investigation indicated that palmitic acid induced excessive generation of ROS, while CsA treatment further stimulated this ROS production.
Oncology reports  •  2019  |  View Paper
Co-… of palmitic acid … CsA resulted in a dose dependent increase in cytotoxicity, suggesting that fatty acid could sensitize cells to CsA-induced cytotoxicity at the therapeutic doses of CsA. A synergized induction of caspase-3/7 activity was also observed, indicating that apoptosis may contribute to the cytotoxicity.
Our data suggest that elevated FFA levels, especially saturated FFA such as palmitic acid , may be predisposing factors for CsA toxicity, and patients with underlying diseases that would elevate free fatty acids may be susceptible to CsA-induced toxicity.
We demonstrated that CsA reduced cellular oxygen consumption which was further exacerbated by palmitic acid , implicating that impaired mitochondrial respiration might be an underlying mechanism for the enhanced toxicity.
Toxicology and applied pharmacology  •  2012  |  View Paper
We found that 200 μM Ca2+ and 20 μM HDA in the presence of CsA effectively induce high-amplitude swelling of mitochondria both in the case of sucrose and in the ionic incubation medium.
Biochemistry (Moscow)  •  2014  |  View Paper