Possible Interaction: Cyclosporine and Olive Oil

“Administration of olive oil alone enhances absorption of cyclosporine A. We also administered cyclosporine A IV to five dogs, with and without a concomitant infusion of fat emulsion solution (Intralipid®).”

“The lowest absorption rate of cyclosporine A was found using olive oil with a percent absorption of 2.52 +/- 1.52% (259 +/- 171 micrograms/g cornea).”

“The mean survival time (MST) of grafts progressively increased from 50 to 89 days as the CsA concentration … dose was increased from 1 to 10 mg/mL. Injection of 30 microL of 20 mg/mL CsA … olive oil prolonged graft survival to beyond 125 … without any signs of rejection.”

“…,cyclosporin … ( olive oil versus cyclosporin A: 0.96 +/- 0.04 versus 0.70 +/- 0.06 ml min-1 100 g body weight, P less than 0.… less than 0.02] and mean arterial pressure (146.7 +/- 6.7 versus 167.3 +/- 2.9 mmHg, P less than 0.05).”

“The kinetics of cyclosporine following administration of either oral solution or cyclosporine in olive oil were variable, with peak concentrations ranging from 450 to 1033 ng/ml and 288 to 648 ng/ml, respectively.”

“Furthermore, doses of CsA (5 mg/kg/day or 1.5 mg/kg/day), which are subtherapeutic when administered with OO , prolonged engraftment of Lewis recipients of Lewis × Brown-Norway F1 hearts when CsA was solubilized with FO.”

“We found that CsA was only effective in significantly prolonging allograft survival when given subcutaneously in olive oil.”

“Regular administration of olive oil alone enhances absorption of oral CsA in a canine model.”