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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Naringin
Research Papers that Mention the Interaction
“The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein, genistin, naringenin, naringin , quercetin and xanthohumol will modulate cellular uptake and permeability (Pe) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin, across Caco-2 and MDCKII-MDR1 cell transport models.”
Plant polyphenols and multidrug resistance: Effects of dietary flavonoids on drug transporters in Caco-2 and MDCKII-MDR1 cell transport models“The active constituents of ginkgo are mainly the bioflavonoids, powerful antioxidants, found very commonly in plants; naringin , in grapefruit, has an adverse effect if taken with a vast number of common drugs including amlodipine, enalapril, cyclosporin , etc.”
“When cyclosporin A (20 mg/kg) was concomitantly administered with naringin (30 mg/kg), the naringin was detected in brain dialysate, but the distribution ratios of liver and bile showed no statistical difference.”
Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a p-glycoprotein modulator.
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