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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Naringenin
Research Papers that Mention the Interaction
“The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein, genistin, naringenin , naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (Pe) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin, across Caco-2 and MDCKII-MDR1 cell transport models.”
Plant polyphenols and multidrug resistance: Effects of dietary flavonoids on drug transporters in Caco-2 and MDCKII-MDR1 cell transport models“ Naringenin , for example, the 4',5',7-hydroxyflavanone found exclusively in grapefruit, can slow hepatic detoxification of prescription drugs like cyclosporine and thus potentially help prevent rejection of transplanted organs.”
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