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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
NAD
Research Papers that Mention the Interaction
“Under these conditions, GSH levels were altered by verapamil and S9788, whereas CSA decreased LDH activity.”
Cyclosporin A, verapamil and S9788 reverse doxorubicin resistance in a human medullary thyroid carcinoma cell line“ Cyclosporine alone inhibited energy production (ATP: 75±9%), the Krebs cycle (4‐13C‐glutamate from 1‐13C‐glucose: 61±27%), and oxidative phosphorylation ( NAD+ : 62±25%) after 4 h of perfusion.”
Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors“Ex vivo 31P magnetic resonance spectroscopy experiments based … that under normoxic conditions, 500 μg/L cyclosporin A significantly reduced mitochondrial energy metabolism (nucleotide triphosphate, 83 ± 9% of … inhibition of the Krebs cycle (glutamate, 77 ± 5%) and oxidative phosphorylation ( NAD+ , 65 ± 14%) associated with an … species (285 ± 78% of control).”
“ NAD+ hydrolysis is Ca(2+)-dependent and inhibited by cyclosporine A (CSA).”
“We have previously shown that NAD+ hydrolysis is inhibited by cyclosporin A and is possible only when some vicinal thiols are cross-linked.”
“We have previously shown that NAD+ hydrolysis and subsequent Ca2+ release are inhibited by cyclosporine A and that they are only possible when some critical thiols are cross-linked or oxidized, e.g. by phenylarsine oxide, gliotoxin, or peroxynitrite.”
“Intriguingly, NAD+ supplementation rescues reduced synaptic ribbon formation in both CSA−/− and CSBm/m mutant cochleae.”
Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome
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