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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cyclosporine and Methylselenocysteine

Research Papers that Mention the Interaction

Here, we clearly demonstrate that when added at the same time as MSCs, CsA negatively affects MSC suppression of T cell proliferation.
Importantly, CsA exposure to IFNγ pre-stimulated MSC before administration, significantly enhanced the potency of MSCs in a human relevant humanised mouse model of acute Graft versus Host Disease.
Stem cell research & therapy  •  2021  |  View Paper
Taken together, our findings suggest that CsA promotes MSC survival in vivo and that the therapeutic efficacy of the combination of MSCs with CsA is superior to each monotherapy.
Clinical science  •  2019  |  View Paper
We propose that pre‐incubation MSCs with CsA inhibits MSC apoptosis through the mitochondrial and BAD pathway.
Scandinavian journal of clinical and laboratory investigation  •  2008  |  View Paper
Moreover, MSCs combined with low-dose CsA protected graft function, but could not prolong animal survival compared with CsA monotherapy, indicating a potential interaction between MSC and CsA activities, possibly allowing reduced CsA doses.
Transplantation proceedings  •  2007  |  View Paper