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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Methylselenocysteine
Research Papers that Mention the Interaction
“Here, we clearly demonstrate that when added at the same time as MSCs, CsA negatively affects MSC suppression of T cell proliferation.”
“Importantly, CsA exposure to IFNγ pre-stimulated MSC before administration, significantly enhanced the potency of MSCs in a human relevant humanised mouse model of acute Graft versus Host Disease.”
Cyclosporine A and IFNγ licencing enhances human mesenchymal stromal cell potency in a humanised mouse model of acute graft versus host disease“Taken together, our findings suggest that CsA promotes MSC survival in vivo and that the therapeutic efficacy of the combination of MSCs with CsA is superior to each monotherapy.”
Cyclosporine A promotes the therapeutic effect of mesenchymal stem cells on transplantation reaction.“We propose that pre‐incubation MSCs with CsA inhibits MSC apoptosis through the mitochondrial and BAD pathway.”
“Moreover, MSCs combined with low-dose CsA protected graft function, but could not prolong animal survival compared with CsA monotherapy, indicating a potential interaction between MSC and CsA activities, possibly allowing reduced CsA doses.”
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