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Last Updated: a month ago

Possible Interaction: Cyclosporine and Melatonin

supplement:

Melatonin

Research Papers that Mention the Interaction

Mitophagy inhibition by cyclosporine A (CsA) partially eliminated the protective effects of melatonin against NP cell apoptosis, suggesting that mitophagy is involved in the protective effect of melatonin on IDD.
Journal of cellular and molecular medicine  •  2019  |  View Paper
Addition of Mel and CsA has shown significant restoration in mitochondrial swelling, Δψm, intracellular ROS measurement and mitochondrial respiration in isolated brain mitochondria.
Mitochondrion  •  2016  |  View Paper
Therefore, these findings indicate that melatonin in combination with CsA protected the cardiac allograft by inhibiting inflammation‑induced apoptosis.
When CsA (5 mg/kg/day) was co‑administered with melatonin (50 mg/kg/day), the survival rate improved (31.6±2.4 days; n=7; P<0.001), compared with that achieved by only 20 mg/kg/day CsA (22±2.8 days; n=7).
Molecular medicine reports  •  2014  |  View Paper
Surprisingly, in the presence of cyclosporin A , a MPT inhibitor, melatonin reduced further mCa(2+)-mediated apoptosis during ionomycin exposure also suggesting its targeting beyond the MPT.
Journal of pineal research  •  2010  |  View Paper
Finally, we show that, (i) melatonin significantly reduces CsA cardiotoxicity acting also on apoptotic processes, and (ii) the reduction in CsA-induced cardiotoxicity is mediated mainly by its antioxidant effect.
Journal of pineal research  •  2009  |  View Paper
Immunosuppressive maintenance therapy with CsA and RPM modulated early melatonin secretion, indicating a specific secondary action of these drugs.
Journal of pineal research  •  2008  |  View Paper
In conclusion our study shows that, (a) melatonin significantly reduces CsA cardiotoxicity, and (b) the reduction in CsA-induced cardiotoxicity was mediated by the binding of melatonin to its membrane receptors.
Journal of pineal research  •  2006  |  View Paper
After CsA plus melatonin , these parameters were reduced in the proximal tubules and restored in the glomerulus.
CsA plus melatonin administration partly prevented these changes.
In conclusion, melatonin attenuated morpho-quantitative alterations induced by CsA in the rat kidney.
Ultrastructural pathology  •  2002  |  View Paper
These findings suggested that Mel probably antagonized the immunosuppressive CsA effects.
International immunopharmacology  •  2001  |  View Paper
Microcalcification in corticomedullary junction seen with CsA was prevented by Mel.
Transplantation  •  1999  |  View Paper