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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Melatonin
Research Papers that Mention the Interaction
“ Melatonin has been demonstrated to protect against calcification in cyclosporine nephrotoxicity.”
“Mitophagy inhibition by cyclosporine A (CsA) partially eliminated the protective effects of melatonin against NP cell apoptosis, suggesting that mitophagy is involved in the protective effect of melatonin on IDD.”
“Background Melatonin has been demonstrated to protect against calcification in cyclosporine nephrotoxicity.”
“Addition of Mel and CsA has shown significant restoration in mitochondrial swelling, Δψm, intracellular ROS measurement and mitochondrial respiration in isolated brain mitochondria.”
“Therefore, these findings indicate that melatonin in combination with CsA protected the cardiac allograft by inhibiting inflammation‑induced apoptosis.”
“When CsA (5 mg/kg/day) was co‑administered with melatonin (50 mg/kg/day), the survival rate improved (31.6±2.4 days; n=7; P<0.001), compared with that achieved by only 20 mg/kg/day CsA (22±2.8 days; n=7).”
“ Melatonin ’s effect in reducing the Ca2+ load greatly diminished when the MPT was inhibited by cyclosporine A , suggesting its pore dependency as well as that a preserved t‐MPT may be superior to a MPT inhibition in protecting mCa2+‐mediated apoptosis.”
“Surprisingly, in the presence of cyclosporin A , a MPT inhibitor, melatonin reduced further mCa2+‐mediated apoptosis during ionomycin exposure also suggesting its targeting beyond the MPT.”
“Finally, we show that, (i) melatonin significantly reduces CsA cardiotoxicity acting also on apoptotic processes, and (ii) the reduction in CsA‐induced cardiotoxicity is mediated mainly by its antioxidant effect.”
Melatonin delivery in solid lipid nanoparticles: prevention of cyclosporine A induced cardiac damage“Immunosuppressive maintenance therapy with CsA and RPM modulated early melatonin secretion, indicating a specific secondary action of these drugs.”
“In conclusion our study shows that, (a) melatonin significantly reduces CsA cardiotoxicity, and (b) the reduction in CsA‐induced cardiotoxicity was mediated by the binding of melatonin to its membrane receptors.”
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