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Last Updated: 2 years ago

Possible Interaction: Cyclosporine and Melatonin

supplement:

Melatonin

Research Papers that Mention the Interaction

Melatonin has been demonstrated to protect against calcification in cyclosporine nephrotoxicity.
Experimental cell research  •  2020  |  View Paper
Mitophagy inhibition by cyclosporine A (CsA) partially eliminated the protective effects of melatonin against NP cell apoptosis, suggesting that mitophagy is involved in the protective effect of melatonin on IDD.
Journal of cellular and molecular medicine  •  2019  |  View Paper
Background Melatonin has been demonstrated to protect against calcification in cyclosporine nephrotoxicity.
BioMed research international  •  2019  |  View Paper
Addition of Mel and CsA has shown significant restoration in mitochondrial swelling, Δψm, intracellular ROS measurement and mitochondrial respiration in isolated brain mitochondria.
Mitochondrion  •  2016  |  View Paper
Therefore, these findings indicate that melatonin in combination with CsA protected the cardiac allograft by inhibiting inflammation‑induced apoptosis.
When CsA (5 mg/kg/day) was co‑administered with melatonin (50 mg/kg/day), the survival rate improved (31.6±2.4 days; n=7; P<0.001), compared with that achieved by only 20 mg/kg/day CsA (22±2.8 days; n=7).
Molecular medicine reports  •  2014  |  View Paper
Melatonin ’s effect in reducing the Ca2+ load greatly diminished when the MPT was inhibited by cyclosporine A , suggesting its pore dependency as well as that a preserved t‐MPT may be superior to a MPT inhibition in protecting mCa2+‐mediated apoptosis.
Journal of pineal research  •  2011  |  View Paper
Surprisingly, in the presence of cyclosporin A , a MPT inhibitor, melatonin reduced further mCa2+‐mediated apoptosis during ionomycin exposure also suggesting its targeting beyond the MPT.
Journal of pineal research  •  2010  |  View Paper
Finally, we show that, (i) melatonin significantly reduces CsA cardiotoxicity acting also on apoptotic processes, and (ii) the reduction in CsA‐induced cardiotoxicity is mediated mainly by its antioxidant effect.
Journal of pineal research  •  2009  |  View Paper
Immunosuppressive maintenance therapy with CsA and RPM modulated early melatonin secretion, indicating a specific secondary action of these drugs.
Journal of pineal research  •  2008  |  View Paper
In conclusion our study shows that, (a) melatonin significantly reduces CsA cardiotoxicity, and (b) the reduction in CsA‐induced cardiotoxicity was mediated by the binding of melatonin to its membrane receptors.
Journal of pineal research  •  2006  |  View Paper
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