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Last Updated: 2 years ago

Possible Interaction: Cyclosporine and Magnesium

supplement:

Magnesium

Research Papers that Mention the Interaction

A number of drugs have been shown to alter magnesium handling ; these include antibiotics such as gentamicin, antineoplastic agents such as cisplatin and immunological suppressive drugs such as cyclosporin.
Magnesium  •  1986  |  View Paper
These observations indicate a modified magnesium steady state in renal transplant recipients treated with cyclosporine.
Total [0.74 (0.70–0.78) vs 0.80 (0.74–0.84) and 0.81 (0.79–0.87) mmol/….46–0.52) vs 0.53 (0.50–0.58) and 0.54 (0.52–0.59) mmol/l, respectively] plasma magnesium were … cyclosporine than in … controls.
Transplant international : official journal of the European Society for Organ Transplantation  •  2003  |  View Paper
Cyclosporine patients showed significantly lower total and ionized circulating magnesium values than the two control groups.
Transplant international : official journal of the European Society for Organ Transplantation  •  1999  |  View Paper
Serum magnesium decreased significantly on cyclosporine (2.5 mg/kg, n = 10, P < 0.01; 5 mg/kg, n = 9, P < 0.0001).
American journal of kidney diseases : the official journal of the National Kidney Foundation  •  1994  |  View Paper
Ionized magnesium correlated inversely with cyclosporin trough level and directly with total cholesterol.
Clinical science  •  1993  |  View Paper
We conclude that short-term use of cyclosporine induces an intracellular shift of magnesium and causes hypomagnesemia.
The Journal of pediatrics  •  1992  |  View Paper
Plasma magnesium was also reduced with cyclosporin treatment.
Since cyclosporin treatment is also associated with magnesium depletion , this could explain the increased occurrence of hypertension in these patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association  •  1992  |  View Paper
Renal magnesium wasting may be added to the spectrum of nephrotoxicity resulting from cyclosporine.
Transplantation  •  1985  |  View Paper
It is suggested that prevention of CsA-induced DNA-binding activation of these transcription factors is at least in part responsible for the beneficial effects of Mg supplementation on CsA nephrotoxicity.
Transplantation  •  2003  |  View Paper
Plasma creatinine and urea were significantly elevated, and magnesium was reduced in the CsA group (N = 6) as compared with controls (CON) (N = 6).
Journal of the American Society of Nephrology : JASN  •  1992  |  View Paper
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