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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Cyclosporine
supplement:
Magnesium
Research Papers that Mention the Interaction
“A number of drugs have been shown to alter magnesium handling ; these include antibiotics such as gentamicin, antineoplastic agents such as cisplatin and immunological suppressive drugs such as cyclosporin.”
Renal handling of magnesium: drug and hormone interactions.“These observations indicate a modified magnesium steady state in renal transplant recipients treated with cyclosporine.”
“Total [0.74 (0.70–0.78) vs 0.80 (0.74–0.84) and 0.81 (0.79–0.87) mmol/….46–0.52) vs 0.53 (0.50–0.58) and 0.54 (0.52–0.59) mmol/l, respectively] plasma magnesium were … cyclosporine than in … controls.”
“ Cyclosporine patients showed significantly lower total and ionized circulating magnesium values than the two control groups.”
“Serum magnesium decreased significantly on cyclosporine (2.5 mg/kg, n = 10, P < 0.01; 5 mg/kg, n = 9, P < 0.0001).”
“Ionized magnesium correlated inversely with cyclosporin trough level and directly with total cholesterol.”
“We conclude that short-term use of cyclosporine induces an intracellular shift of magnesium and causes hypomagnesemia.”
“Plasma magnesium was also reduced with cyclosporin treatment.”
“Since cyclosporin treatment is also associated with magnesium depletion , this could explain the increased occurrence of hypertension in these patients.”
“ Renal magnesium wasting may be added to the spectrum of nephrotoxicity resulting from cyclosporine.”
“It is suggested that prevention of CsA-induced DNA-binding activation of these transcription factors is at least in part responsible for the beneficial effects of Mg supplementation on CsA nephrotoxicity.”
Activation of transcription factors AP-1 and NF-&kgr;B in chronic cyclosporine A nephrotoxicity: role in beneficial effects of magnesium supplementation1“Plasma creatinine and urea were significantly elevated, and magnesium was reduced in the CsA group (N = 6) as compared with controls (CON) (N = 6).”
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