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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Leucine
Research Papers that Mention the Interaction
“We have previously reported that CsA impairs the activity of the lysosomal enzymes cathepsin B and L in human gingival fibroblasts (HGFs).”
cAMP-response element binding protein (CREB) regulates cyclosporine-A-mediated down-regulation of cathepsin B and L synthesis“For all mitogens tested (PHA, Con A, OKT3, and Leu 4 ), expression of IL2R and TR, as well as DNA synthesis (3H-thymidine incorporation), were significantly reduced in the presence of CsA (0.5 microgram/ml).”
“The hypertrophy-associated increase in ICa L and the accelerated recovery from inactivation were blocked by cyclosporin A. Conclusions—These data reveal regional variation in the electrophysiological response within the left ventricle by way of a mechanism involving upregulated Ca2+ current and calcineurin.”
Electrical Remodeling in Pressure-Overload Cardiac Hypertrophy: Role of Calcineurin“A small dose-dependent reduction in [3H]leucine incorporation was observed in microsomes isolated from rat liver when cyclosporine A was added in high concentrations (5 and 6% at 25 and 100 micrograms/ml).”
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