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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Inulin
Research Papers that Mention the Interaction
“Results: Clearances of inulin and PAH decreased progressively after CsA dosage while renal vascular resistance increased.”
Pathophysiology of Cyclosporine-Induced Nephrotoxicity in Humans: A Role for Nitric Oxide?“ Inulin clearance was impaired by ciclosporin with 93.5 +/- 4.4 ml/min/1.73 m2 as compared to 121 +/- 6.6 ml/min/1.73 m2 (p less than 0.05) in patients of group 2.”
“ CsA decreased the clearances of inulin and p-aminohippuric acid (PAH) in a dose-dependent manner.”
Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity.“ CsA , administered at 15 mg/kg/body weight (BW) subcutaneously for 10 days, caused a decrease in glomerular filtration rate, with inulin clearance of 0.33+/-0.04 vs. 1.11+/-0.06 ml/min/100 g BW (P<0.01 vs. control).”
“ CsA (10 mg kg-1 day-1) decreased inulin and PAH clearances, without affecting the PAH extraction.”
“However, inulin clearance decreased greater than four-fold in immunized rats given cyclosporine for 7 days.”
“ CSA produced acute and concentration-dependent reductions in renal plasma flow (left kidney) and in the clearances of p-aminohippuric acid and inulin (both kidneys).”
“Similarly, subacute administration of cyclosporine A (20 mg/kg.day for 3 days) resulted in significant reductions in base-line PAH and inulin clearances which were normalized by administration of fenoldopam.”
“In contrast, a 63% decrease in inulin clearance was observed following the administration of intravenous cyclosporine (0.1 ml).”
“By comparison an infusion of cyclosporine (20 mg/kg) caused a 50% decrease in inulin clearance and a fall in renal plasma flow from 2.6 +/- 0.3 to 0.9 +/- 0.3.”
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