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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Homocysteine
Research Papers that Mention the Interaction
“Administration of cyclosporine A caused a significant increase in homocysteine and cysteine concentration.”
Blood concentration of aminothiols in children with relapse of nephrotic syndrome“Folate and cyclosporine levels had less significant effects on Hcy concentrations.”
“Renal transplant … on cyclosporine had significantly higher plasma homocysteine concentrations than those not on cyclosporine (19.5 +/- 7.6 vs. 16.2 +/- 4.8 mumol/L, P < 0.05), and the patients without a transplant (19.5 +/- 7.6 vs. 16.0 +/- 4.9 mumol/L, P < 0.01).”
“Comparing to Glu, the effects of Hcy were slightly less expressed and less sensitive to CsA , while FK506 did not modify mitochondrial alterations.”
Excitotoxic neuronal injury in acute homocysteine neurotoxicity: Role of calcium and mitochondrial alterations“ Cyclosporine (CsA) has been suggested to interfere with folate-assisted remethylation of homocysteine , thus causing hyperhomocysteinemia.”
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