Possible Interaction: Cyclosporine and Glucose

“Venous whole-blood glucose concentration (mean ± … min after the ingestion of oral glucose was significantly … both the cyclosporin A (P < 0.05) and FK 506 (P < 0.01) treatment groups compared with the control ….6 ± 0.5 vs. 8.8 ± 0.9 vs. 5.2 ± 0.2 mM, respectively).”

“Results Treatment with cyclosporin A increased hepatic glucose production and gluconeogenic gene expression.”

“Instead, cyclosporine transiently stimulated ceramide formation, decreased the cytosolic ATP concentration and potentiated the decline of cytosolic ATP concentration following glucose depletion.”

“ Oral CsA reduced in vivo fat absorption from the diet, and all doses and routes of administration of CsA caused reduction of both active glucose uptake and of passive fatty acid absorption by the intestine in vitro (4).”

“The maximal transport rate (Vmax) for the active jejunal uptake of D-glucose was increased in HD-Rap and CsA , but not in the HD-Rap/CsA-treated animals.”

“In particular, calmodulin antagonists, FK506, and cyclosporin , immunosuppressants that inhibit the calcium-dependent phosphatase calcineurin, suppress ERK1/2 activation by both glucose and GLP-1.”

“Results indicate that cyclosporin A simultaneously decreases and protects cell glucose and energy metabolism.”

“ Cyclosporin A at micromolar concentration decreases the respiration of Ehrlich ascites tumour cells (with pyruvate as substrate) but prevents the inhibition of oxygen uptake produced by glucose or deoxyglucose (the Crabtree effect).”

“Results show that CsA seems to modify glucose load distribution; in fact it influences considerably glycemia and hepatic, cardiac and muscular glycogen levels, particularly after glucose load.”

“The present experiments suggest that CsA has an antagonist action on insulin release elicited by glucose.”

“Plasma levels of urea, aspartate aminotransferase (AST) and glucose were significantly higher in the cyclosporin A-treated group than the control group.”