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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cyclosporine and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein , genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (Pe) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin, across Caco-2 and MDCKII-MDR1 cell transport models.
Xenobiotica; the fate of foreign compounds in biological systems  •  2006  |  View Paper
The … to genistein caused Mcl-…; furthermore, cyclosporin A (an inhibitor of mitochondrial permeability transition pore) almost completely abolished genistein-induced loss of mitochondrial membrane potential, and induced a 30% …-term treatment (48 h) of genistein, suggesting the involvement of mitochondrial stress in the late phase of genistein-induced effect.
Biochemical pharmacology  •  2007  |  View Paper
Addition of the tyrosine protein kinase inhibitor genistein or of the immunosuppressive agent cyclosporin A abrogated these effects.
Blood  •  1994  |  View Paper