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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“In one study, the entrance of CsA into the brain inhibited gamma-aminobutyric acid neurotransmission in rats, resulting in convulsions [3].”
Cyclosporin A-induced posterior reversible encephalopathy syndrome in an adolescent with steroid-resistant nephrotic syndrome“In this study, we investigated whether the facilitation of central γ‐amino butyric acid GABA ) neurotransmission blunts these favorable influences of CSA.”
“These results demonstrate that the activation of central GABAB receptors either directly via baclofen or indirectly following interventions that boost GABA levels in central synapses counterbalances the rectifying action of CSA on endotoxemia.”
Activation of central GABAB receptors offsets the cyclosporine counteraction of endotoxic cardiovascular outcomes in conscious rats“The GABA turnover estimated by measuring aminooxyacetic acid-induced GABA accumulation in the mouse brain was significantly inhibited by cyclosporine (50 mg/kg, i.p.).”
“Okadaic acid, a protein phosphatase inhibitor, stimulated transport 2.5-fold; a 4-fold increase in GABA uptake occurred when oocytes were treated with cyclosporin A , a specific inhibitor of protein phosphatase 2B.”
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