Possible Interaction: Cyclosporine and Calcium Supplement

“ Calcium content in erythrocytes of patients receiving Sandimmun was 27.6% higher than in healthy persons.”

“Here we show that the candidate ALS drug dexpramipexole (DEX; KNS-…,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) and cyclosporine A (CSA) inhibited increases in ion … brain-derived mitochondria induced by calcium or treatment with a proteasome inhibitor, although only …-induced permeability transition in liver-derived mitochondria.”

“ Cyclosporin A or the caspase‐8 inhibitor Z‐IETD‐FMK blocked AE‐induced loss of mitochondrial membrane potential and prevented increases in reactive oxygen species and Ca++.”

“Collectively, these data indicate that CsA inhibits collagen phagocytosis by blocking calcium release from ER stores and may perturb functional interactions between the ER and mitochondria that regulate calcium stores.”

“Direct measurements of Ca2+ in mitochondrial and ER stores showed that CsA only slightly inhibited collagen bead-induced discharge of calcium from mitochondria, but almost completely blocked discharge from ER stores.”

“These results strongly suggest the existence of two distinct mechanisms leading to cytochrome C release: one stimulated by calcium and inhibited by cyclosporin A , the other Bax dependent, Mg2+ sensitive but cyclosporin insensitive.”

“Since CsA is known to block a deleterious permeability transition (PT) in mitochondria from several tissues in response to calcium accumulation and oxidative stress, the results on CsA effects in forebrain ischaemia support a mitochondrial origin for the delayed cell death.”

“The nuclear translocation is regulated by calcium and calcineurin and inhibited by cyclosporin A and FK506.”

“… CsA … calcium concentration as determined by a flow cytometry assay (p < 0.05).ConclusionThe results presented in this report demonstrated that the synergistic effect of CsA … in suppressing the expression of biofilm related and drug-resistant genes, and reducing cellular surface hydrophobicity, as well as evoking intracellular calcium concentration.”

“In conclusion, we found that L‐type Ca2+ channel blockers and subtherapeutic doses of cyclosporin act additively to suppress the Ca2+‐calcineurin‐NFAT signalling pathway, leading to inhibition of T cell activity.”

“ CsA significantly inhibited enhancement of plasma membrane permeability, change of intracellular free calcium ions and decrease of mitochondria transmembrane potential, also greatly delayed the progress of apoptosis.”