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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Cyclosporine
supplement:
Alpha-lipoic acid
Research Papers that Mention the Interaction
“Concomitant use of α-lipoic acid and cyclosporine significantly increased nitric oxide production, cyclooxygenase-2 and miR-210 gene expression compared to all other studied groups.”
“The current findings suggest that facilitation of nitric oxide/cyclooxygenase-2/miR-210 cascade constitutes, at least partially, the cellular mechanism by which concurrent use of α-lipoic acid and cyclosporine aggravates colon damage.”
“We proposed that α-lipoic acid and cyclosporine co-administration might modulate their individual effects.”
Co-administration of α-lipoic acid and cyclosporine aggravates colon ulceration of acetic acid-induced ulcerative colitis via facilitation of NO/COX-2/miR-210 cascade.“Concomitant treatment with LA (20 mg/kg body weight, orally for 21 days showed that the oxidative stress alteration were significantly decreased in CsA treated renal tissue.”
“In conclusion, dietary supplementation with alpha-tocopherol and alpha-lipoic acid enhanced the erythrocyte antioxidant defence and reduced nephrotoxicity in cyclosporine treated animals.”
“In summary, dietary supplementation with α‐tocopherol and α‐lipoic acid attenuated the cyclosporine‐induced decrease in erythrocyte superoxide dismutase activity and attenuated cyclosporine‐induced vascular dysfunction.”
“ Cyclosporine A , a potent inhibitor of mitochondrial MPT, inhibited all these events induced by LA.”
“The release stimulated by alpha-lipoic acid is inhibited by cyclosporine A and is more effective when the pyridine nucleotides are oxidized.”
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