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Last Updated: 2 years ago

Possible Interaction: Cyclosporine and Alpha-lipoic acid

Research Papers that Mention the Interaction

Concomitant use of α-lipoic acid and cyclosporine significantly increased nitric oxide production, cyclooxygenase-2 and miR-210 gene expression compared to all other studied groups.
The current findings suggest that facilitation of nitric oxide/cyclooxygenase-2/miR-210 cascade constitutes, at least partially, the cellular mechanism by which concurrent use of α-lipoic acid and cyclosporine aggravates colon damage.
We proposed that α-lipoic acid and cyclosporine co-administration might modulate their individual effects.
Toxicology and applied pharmacology  •  2015  |  View Paper
Concomitant treatment with LA (20 mg/kg body weight, orally for 21 days showed that the oxidative stress alteration were significantly decreased in CsA treated renal tissue.
International immunopharmacology  •  2007  |  View Paper
In conclusion, dietary supplementation with alpha-tocopherol and alpha-lipoic acid enhanced the erythrocyte antioxidant defence and reduced nephrotoxicity in cyclosporine treated animals.
Basic & clinical pharmacology & toxicology  •  2006  |  View Paper
In summary, dietary supplementation with α‐tocopherol and α‐lipoic acid attenuated the cyclosporine‐induced decrease in erythrocyte superoxide dismutase activity and attenuated cyclosporine‐induced vascular dysfunction.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons  •  2006  |  View Paper
Cyclosporine A , a potent inhibitor of mitochondrial MPT, inhibited all these events induced by LA.
Physiological chemistry and physics and medical NMR  •  2006  |  View Paper
The release stimulated by alpha-lipoic acid is inhibited by cyclosporine A and is more effective when the pyridine nucleotides are oxidized.
Biochemical pharmacology  •  1996  |  View Paper