Possible Interaction: Cyclosporine and Adrenocorticotropic Hormone

“Treatment with CsA significantly reduced plasma concentrations of adrenocorticotropic hormone (ACTH), cortisol, and noradrenaline whereas adrenaline levels and state anxiety remained unaffected.”

“ Cyclosporine was also effective in restoring 24-h rhythmicity of serum ACTH and TSH, but not of prolactin, levels.”

“In control animals, CsA reduced basal anterior pituitary POMC and IL-6 mRNA and decreased plasma levels of ACTH and B. Adjuvant-injected animals that were treated with CsA showed no clinical signs of AA.”

“…,CsA inhibited the arthritis-induced increases in pituitary … IL-6 mRNA levels and in circulating ACTH and B. In vitro, CsA reduced the POMC mRNA content of cultured anterior pituitary cells and diminished … effects of corticotropin-releasing hormone (CRH) on POMC mRNA expression and ACTH secretion from these cells.”

“However, the decrement in ACTH levels by cyclosporine did not always result in corresponding decrement of serum corticosterone levels.”

“… ACTH was also suppressed … coadministered with cyclosporine plus 1 or 4 mg/kg/day of prednisolone than in rats administered with each dose of prednisolone alone (37.5% greater …; p less than 0.025, or 25.7% greater for 4 mg/kg prednisolone group; p less than 0.025).”