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Last Updated: 4 months ago

Possible Interaction: Cyclosporine and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

Treatment with CsA significantly reduced plasma concentrations of adrenocorticotropic hormone (ACTH), cortisol, and noradrenaline whereas adrenaline levels and state anxiety remained unaffected.
Pharmacology Biochemistry and Behavior  •  2014  |  View Paper
RESULTS In 12 patients who received combined therapy with cyclosporin and corticotropin , clinical severity was distinctly improved in 11 patients (92%) by combination therapy within 2 weeks and 7 patients (58.3%) entered into complete remission with salicylazosulfapyridine or 5-aminosalicylic acid alone.
Hepato-gastroenterology  •  2003  |  View Paper
In control animals, CsA reduced basal anterior pituitary POMC and IL-6 mRNA and decreased plasma levels of ACTH and B. Adjuvant-injected animals that were treated with CsA showed no clinical signs of AA.
…,CsA inhibited the arthritis-induced increases in pituitary … IL-6 mRNA levels and in circulating ACTH and B. In vitro, CsA reduced the POMC mRNA content of cultured anterior pituitary cells and diminished … effects of corticotropin-releasing hormone (CRH) on POMC mRNA expression and ACTH secretion from these cells.
Journal of Neuroimmunology  •  1992  |  View Paper
However, the decrement in ACTH levels by cyclosporine did not always result in corresponding decrement of serum corticosterone levels.
Research communications in chemical pathology and pharmacology  •  1988  |  View Paper