Possible Interaction: Cycloserine and Glycine

“Baseline glutamate level and change in glycine level significantly correlated with response of negative symptoms to 50-mg D-cycloserine.”

“Although glycine administration reduced DCS plasma levels, glycine accentuated DCS effects previously associated with the NMDA receptor antagonists, ketamine and ethanol.”

“In doing so, it tested the hypothesis that raising brain glycine concentrations would accentuate the antagonist-like effects of the glycine(B) partial agonist, D-cycloserine (DCS).”

“Stimulation of binding induced by DCS in the presence of fixed concentrations of glycine resulted in a family of dose-response curves, consistent with the antibiotic having the property of a partial agonist at this glycine site.”

“ Glycine , which is a natural full agonist that acts at the glycine site, enhanced the seizure threshold-increasing effect of D-cycloserine.”

“The antinociceptive effect of intra‐mPFC DCS infusions was mimicked by NMDA and glycine , and blocked by HA 966.”

“These findings indicate that the use of GLY and DCS results in attenuation of VCM in rats and may have an effect on TD in humans.”

“This sensorimotor gating deficit was antagonized by systemic pretreatment of the rats with the glycine site agonist D-cycloserine , indicating that the effect of 7-CLKYN was due to a blockade of the NMDA receptor associated glycine binding site.”

“ L-cycloserine inhibited the metabolism, as did a number of amino acids including glycine , serine and threonine.”

“Maximal NMDA responses in the presence of DCS were only 40-50% of those in the presence of glycine.”

“Since the primary access of d-cycloserine in E. coli is via the d-alanine-glycine system, glycine might be expected to be a better antagonist of d-cycloserine inhibition than l-alanine.”

“ d-Cycloserine was an effective inhibitor of glycine and d-alanine accumulation, and l-cycloserine was an effective inhibitor of l-alanine transport.”