Possible Interaction: Cycloserine and Gamma-Aminobutyric Acid

“In HR animals, the pretreatment of rats with d-cycloserine and midazolam significantly increased the local concentration of GABA and inhibited the expression of contextual fear.”

“At a dose (30 mg/kg) which elevated the level of GABA almost 4-fold, L-cycloserine moderately increased the content of alanine and slightly reduced that of aspartate, glutamate and glycine in the brain.”

“ L-Cycloserine dose-dependently inhibited the activity of gamma-aminobutyric acid (GABA)-transaminase (GABA-T) and elevated the level of GABA in whole mouse brain with a peak effect 3-4 hr after a single intraperitoneal injection.”

“By selectively inhibiting GABA transaminase, L-cycloserine presumably increases the amount of GABA available for release.”

“The intramuscular administration of L-cycloserine , gabaculine, and aminooxyacetic acid caused significant, time-dependent increases in the gamma-aminobutyric acid (GABA) content of both whole brain and synaptosomal-enriched preparations obtained from the tissue, a linear relationship being observed between the two parameters.”

“The animals were treated with cycloserin , acting as an inhibitor of the GABA transaminase, in order to enhance the GABA content.”

“ D‐Cycloserine and β‐hydrazino‐propionic acid also inhibited [3H]GABA uptake, but the amounts required were considerably in excess of those needed to inhibit GABA:glutamate transaminase.”

“Rats and guinea pigs treated acutely or chronically with cycloserine exhibited high concentrations of γ-aminobutyric acid in the brain, a finding consistent with γ-aminobutyric-α-ketoglutaric transaminase inhibition by cycloserine in vivo .”