Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Cyclophosphamide and Vitamin C

Research Papers that Mention the Interaction

Cyclophosphamide also evoked a decrease in the levels of nonenzymatic antioxidants, such as reduced gluthatione, vitamin C , and vitamin E as well as the total antioxidant status.
Toxicology mechanisms and methods  •  2003  |  View Paper
Vitamin C was ineffective against Trp-P-2, but caused an overall increase of SCEs induced by CP.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  1998  |  View Paper
Our findings support the potential use of CP in a liposomal formulation doped with vitamin C to diminish the potential side effects of the agent.
General physiology and biophysics  •  2012  |  View Paper
The combination treatment with ascorbic acid plus cyclophosphamide caused further changes in tumor cells showing disintegration in the cell surface membrane, disruption in the nuclear membrane and roundish mitochondria with reduction and disruption in the mitochondrial cristae.
European journal of pharmacology  •  2010  |  View Paper
Besides, CP treatment decreased plasmatic vitamin C (VIT C) levels and induced bladder macroscopical and microscopical damages.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer  •  2010  |  View Paper
The present study deals with exploration of lipid peroxidation induction capacity of cyclophosphamide, an anticancer drug, and in vitro evaluation of ascorbic acid as a suppressor of cyclophosphamide induced lipid peroxidation.
Acta poloniae pharmaceutica  •  2005  |  View Paper
Cyclophosphamide also evoked a decrease in the level of non-enzymatic antioxidants, such as reduced glutathione and vitamins C , E and A, as well as total antioxidant status.
Drug metabolism and drug interactions  •  2002  |  View Paper
AsA was found to be effective in reducing MN frequency induced by CP and BLM.
Mutation research  •  1999  |  View Paper
The combined effect of cyclophosphamide and ascorbic acid on plasma lipids and lipoprotein profiles are important since, ascorbic acid encumbered the lipid abnormalities initiated by cyclophosphamide during cancer chemotherapy.
These results suggested, that some clinical entanglement of cyclophosphamide was refrained by co-administration of ascorbic acid in tumor stress condition.
Cancer biochemistry biophysics  •  1998  |  View Paper
This anticlastogenic effect was clearly correlated to a beneficial effect on embryolethality at term when 200 mg/kg ascorbic acid was given in combination with 40 mg/kg CPA.
Teratogenesis, carcinogenesis, and mutagenesis  •  1989  |  View Paper
Show More