Possible Interaction: Cyclophosphamide and Vitamin A

“The … CP was strongly reduced by …-carotene, canthaxanthin, and retinol (ID50-values: 67-112 nmol ml-1 top agar, 50-63% maximum inhibition at 1 micromol ml-1 top agar), … beta-cryptoxanthin, and lutein (45% and 28%, respectively), and only marginally or, not at all, by all remaining carotenoids.”

“Supplemental vitamin A also moderated the effects of wounding, tumor, and tumor therapies (local irradiation and cyclophosphamide ) on the increase in adrenal size, leukopenia, thrombocytopenia, and thymic involution (except the last was not moderated in the cyclophosphamide-treated tumor-bearing rats).”

“Supplemental vitamin A mitigated the impaired wound healing in the cyclophosphamide-treated tumor-bearing mice.”

“The splenic enlargement in the untreated tumor-bearing wounded rats and in those treated … lessened by supplemental vitamin A. We hypothesize that these anti-stress effects of vitamin A underlie, in part, its action in mitigating the impaired wound …-bearing mice, including those treated by local irradiation or cyclophosphamide.”

“ Vitamin A excess exerted the protective effect in acute intoxication with bromobenzene, cyclophosphamide and dimethylnitrosamine.”

“ Rol effectively inhibited SCE and CA induced by AFB and CPP in a dose-dependent manner, but it had no effect on SCE induced by BA, BP, DMBA, MCA, EMS, and MMNG.”

“The possibility that Rol exerts its anticarcinogenic effects by inhibiting certain forms of the cytochrome P-450 isoenzymes required for activation of precarcinogens, such as AFB and CPP but not those enzymes required by BA, BP, DMBA, and MCA, is discussed.”

“In the Ames test in Salmonella typhimurium TA1535 with mouse-liver S-9 mix, the addition of retinol , retinyl acetate or retinyl palmitate caused a dose-dependent inhibition of cyclophosphamide mutagenicity.”

“After combined … of cyclophosphamide and vitamin A to the tumor-bearing rats, a significant decrease was found in tumor glycosaminoglycans sensitive to lysosomal hyaluronidase, such as the nonsulfated glycosaminoglycans or chondroitin sulfate A and/or C. An increased release of the lysosomal enzymes into ascites was also consistently found.”

“It is suggested that this reduction in tumor glycosaminoglycans reflects the synergistic effect of the combined administration of cyclophosphamide and vitamin A on the survival time of tumor-bearing rats in this investigation.”

“Combined treatment with the cytotoxic agent and a lysosomal labilizer, vitamin A , increased both the inhibitory effect of cyclophosphamide and the acid phosphatase activity in the tumor cells.”