Possible Interaction: Cyclophosphamide and Taurine

“Compared with the cyclophosphamide group, … were found increased in the taurine (of … cyclophosphamide groups : the count of bone marrow nucleate cells, the count and classification of white blood cells, the spleen index, … index, the lymphocyte proliferation and the phagocytic activity of peritoneal macrophage, peripheral blood neutrophilic granulocyte and monocyte.”

“In conclusion, taurine can enhance the function of the leucocyte after chemotherapy of cyclophosphamide.”

“The tumor inhibition rates on Lewis lung carcinoma in taurine (40 mg/kg, 80 mg/kg, 160 mg/kg) combined with cyclophosphamide group were higher than that in the cyclophosphamide alone group.”

“This study aimed to investigate the enhancing effect of taurine on the function of leucocyte after chemotherapy of cyclophosphamide.”

“All the results described above show taurine is functioning for tumor inhibition, and has obvious synergic effect while treated with CTX as chemotherophy.”

“Pretreatment of rats with daily intraperitoneal injection of taurine plus niacin 7 days prior to and 2 days after cyclophosphamide insult significantly inhibited the development of lung injury, prevented the alterations in lavage fluid biomarkers associated with inflammatory reactions, with less lipid peroxidation and restoration of antioxidants.”