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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclophosphamide
supplement:
Squalamine
Research Papers that Mention the Interaction
“ Squalamine as a single agent had only a modest effect on the growth of the primary Lewis lung tumor but increased the tumor growth delays produced by cyclophosphamide , cisplatin, paclitaxel and 5-fluorouracil by 2.4- to 3.8-fold compared with the anticancer drugs alone.”
“While squalamine administration alone produced only a modest effect on the growth of the 13,…, there were increases in tumor growth delay of 1.9- to 2.5-fold when squalamine was administered … with cyclophosphamide , cisplatin and paclitaxel compared with the tumor … delays observed with the chemotherapeutic agents alone.”
Potential of the aminosterol, squalamine in combination therapy in the rat 13,762 mammary carcinoma and the murine Lewis lung carcinoma.“Preclinical studies with squalamine have shown additive benefits in tumor growth delay when squalamine is combined with cisplatin, paclitaxel, cyclophosphamide , genistein or radiation therapy.”
Antiangiogenic Steroids in Human Cancer Therapy
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