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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclophosphamide
supplement:
Resveratrol
Research Papers that Mention the Interaction
“Additional analyses indicated the significant up-regulation (P = 0.001) of tumor suppressor p53 and p53-regulated pro-apoptotic Bax and Fas in MCF-7 cells following CPA treatment in combination with RES , which may contribute to the enhancement of the antitumor effect of CPA.”
“Interestingly, we found that RES significantly enhances the caspase-mediated cytotoxic activity of CPA on MCF-7 cells in vitro.”
“ RES at 50 microM decreases … IC(50) value of CPA from 10 to 5 mM. FACS data reveals CPA or RES alone mediated G0/G1 and S phase arrest, while … combination of these drugs released both the arrests and results in an increase in the sub G0/G1 peak.”
Caspase mediated enhanced apoptotic action of cyclophosphamide- and resveratrol-treated MCF-7 cells.“Conclusions: RES may be beneficial adjuvant that confers multi-organ protection against CyP toxicity via antioxidant and anti-inflammatory mechanisms.”
Inhibition of NF-κB/TNF-α pathway may be involved in the protective effect of resveratrol against cyclophosphamide-induced multi-organ toxicity“Conclusions Res can prevent the primordial follicle activation and decrease apoptosis induced by Cy.”
The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study
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