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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cyclophosphamide and Resveratrol

Research Papers that Mention the Interaction

Additional analyses indicated the significant up-regulation (P = 0.001) of tumor suppressor p53 and p53-regulated pro-apoptotic Bax and Fas in MCF-7 cells following CPA treatment in combination with RES , which may contribute to the enhancement of the antitumor effect of CPA.
Interestingly, we found that RES significantly enhances the caspase-mediated cytotoxic activity of CPA on MCF-7 cells in vitro.
RES at 50 microM decreases … IC(50) value of CPA from 10 to 5 mM. FACS data reveals CPA or RES alone mediated G0/G1 and S phase arrest, while … combination of these drugs released both the arrests and results in an increase in the sub G0/G1 peak.
Journal of pharmacological sciences  •  2009  |  View Paper
Conclusions: RES may be beneficial adjuvant that confers multi-organ protection against CyP toxicity via antioxidant and anti-inflammatory mechanisms.
Immunopharmacology and immunotoxicology  •  2017  |  View Paper
Conclusions Res can prevent the primordial follicle activation and decrease apoptosis induced by Cy.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology  •  2021  |  View Paper