Possible Interaction: Cyclophosphamide and Quercetin

“In conclusion, the natural antioxidants oleuropein and quercetin counteract the Cyclo induced hepatotoxicity through activation of Nrf2/HO‐1 signaling pathway with subsequent suppression of oxidative stress and inflammation.”

“Further studies are required to assess the potential benefits associated with the combined use of cyclophosphamide plus quercetin in advanced bladder cancer patients.”

“ Quer attenuated the biochemical markers and histopathological changes induced by CYP.”

“ Quercetin treatment suppressed the accumulation of malondialdehyde and increased glutathione peroxidase levels during doxorubicin and cyclophosphamide treatment (P <.05) Conclusions.”

“In the biochemical result (although oxidative parameters were increased in favor of tissue damage) QUE administration revealed attenuated CYP toxicity in the rats 'lungs.”

“Higher total nitrate/nitrite levels were observed in the myocardial tissue treated with QE and VA in combination with CP.”

“In addition, the pre-treatment with VA and QE together with CP significantly decreased chromosome aberrations and aberrant cells compared to CP alone.”

“Results from the current study suggest that QE and VA supplementation attenuates CP induced cardiotoxicity, urotoxicity and genotoxicity through a mechanism related to their ability to decrease oxidative stress and inflammation, and at least in part to its protective effects on the cardiovascular system.”

“Furthermore, quercetin prevented cyclophosphamide-induced apoptosis in early growing follicles and early antral follicles, maintained anti-Müllerian hormone levels secreted by these follicles, and preserved the quiescence of the primordial follicle pool, as determined by intranuclear Foxo3a staining.”

“Results Quercetin attenuated the cyclophosphamide-induced reduction in dormant primordial follicles.”

“On the basis of results, quercetin significantly can decrease teratogenicity induced by CP.”