Possible Interaction: Cyclophosphamide and Ovalbumin

“It could be demonstrated that Cp led to a reduction of the number of lymphocytes, plasma cells and fibroblasts in the synovial membrane, the … its administration around the point of HIA elicitation, an even stronger inhibition of lymphocytes and plasma-cells was only to be expected when Cp … ovalbumin ….”

“The production of IL-5 protein and mRNA were greatly enhanced in the cells from mice given CY with ovalbumin (OVA), compared with mice given either agent alone.”

“Furthermore, the tolerant state induced by feeding 25 mg OVA was only partially prevented by 100 mg/kg cyclophosphamide ( CY ) while the suppressed CMI after feeding 2 mg OVA was completely blocked by CY pretreatment.”

“Migration inhibition developed only if an ovalbumin feed was preceded by cyclophosphamide administration ; sensitization developed within 24 hr of a single ovalbumin feed, persisted for 14 days and could be recalled on secondary oral challenge with ovalbumin.”

“ Cyclophosphamide 30 mg/kg given 2 days before the booster injection or the primary sensitization results in a marked increase in bronchial reactivity when challenged with ovalbumin.”

“The … of cyclophosphamide (CY, 300 mg/kg), given 3 days before sensitization with OA in FIA, was also studied in an attempt to clarify further its role in increasing the intensity of skin reactions and its effect on the passive transfer of skin reactivity described in the preceding paper.”

“WHEN guinea pigs … dose of cyclophosphamide (CY, 300 mg kg−… sensitisation with either ovalbumin in Freund's incomplete adjuvant (OA/FIA) or 2,4 dinitrofluorobenzene (DNFB), the resultant Jones-Mote or contact … 1 week later are increased in intensity and induration and prolonged as compared to control animals1,2.”