Possible Interaction: Cyclophosphamide and Melatonin

“SummaryA significant myeloprotective effect of melatonin in mice treated with etoposide, cyclophosphamide or carboplatin has been reported.”

“Expert opinion: Our findings clearly demonstrate that melatonin has a protective role in the prevention of chemotherapy-induced nephrotoxicity which may be caused by different chemotherapy agents such as cyclophosphamide , cisplatin, doxorubicin, methotrexate, oxaliplatin, etoposide, and daunorubicin.”

“The use of melatonin as monotherapy or in combination with cyclophosphamide was followed by a signifi cant decrease in Bcl-2 expression in carcinosarcoma cells.”

“Our results revealed that MEL might be useful for prevention of the nephrotoxicity induced by CP through ameliorative effects on biochemical indices and oxidative stress parameters.”

“A decrease in VEGF-A expression in the tumor node and salivary gland was found after monotherapy with melatonin and cyclophosphamide and, especially, after combined treatment, which proves maximum therapeutic efficiency of combined administration of chemical agents with various mechanisms of action.”

“Our results reveal that melatonin produces a potent hepatoprotective mechanism against CP.”

“Therefore, melatonin could be a potent candidate to use concomitantly as a supplement agent against hepatotoxicity of CP for the patients undergoing chemotherapy.”

“The number (mean ± SE) of chromosomal … in pinealectomized (PINX) animals treated with melatonin … CP (2.50 ± 0.50/100 cells) was lower than that obtained for PINX animals injected with CP (12 ± 1.8/100 cells), thus showing a reduction of 85.8% in the number of chromosomal aberrations.”

“ CP injection resulted in severe cystitis with increase in voiding behaviors, histological damage, mast cell proliferation, SP, and proinflammatory cytokine expression, which were significantly downregulated by melatonin pretreatment.”

“However, cleft palate, spina bifida and exencephalyincidence were 62.5%, 45.83% and 4.16% range in the group which received CP plus melatonin (10mg/kg), respectively.”

“ Melatonin co-treatment prevented the development of hyperplastic urothelium, statistically significantly decreased proliferation and apoptotic indices after four and five doses of CP and caused higher differentiation state of superficial urothelial cells.”