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Last Updated: 3 months ago

Possible Interaction: Cyclophosphamide and Melatonin

Research Papers that Mention the Interaction

SummaryA significant myeloprotective effect of melatonin in mice treated with etoposide, cyclophosphamide or carboplatin has been reported.
British Journal of Cancer  •  1999  |  View Paper
Expert opinion: Our findings clearly demonstrate that melatonin has a protective role in the prevention of chemotherapy-induced nephrotoxicity which may be caused by different chemotherapy agents such as cyclophosphamide , cisplatin, doxorubicin, methotrexate, oxaliplatin, etoposide, and daunorubicin.
Expert opinion on drug metabolism & toxicology  •  2018  |  View Paper
The use of melatonin as monotherapy or in combination with cyclophosphamide was followed by a signifi cant decrease in Bcl-2 expression in carcinosarcoma cells.
Bulletin of Experimental Biology and Medicine  •  2010  |  View Paper
RESULTS Our results indicate that overall MLT exerts a remarkable countering activity towards leukopenia and anemia in the early phase of administration of CP.
Neuro endocrinology letters  •  2009  |  View Paper
Our results revealed that MEL might be useful for prevention of the nephrotoxicity induced by CP through ameliorative effects on biochemical indices and oxidative stress parameters.
Fundamental & clinical pharmacology  •  2017  |  View Paper
A decrease in VEGF-A expression in the tumor node and salivary gland was found after monotherapy with melatonin and cyclophosphamide and, especially, after combined treatment, which proves maximum therapeutic efficiency of combined administration of chemical agents with various mechanisms of action.
Bulletin of Experimental Biology and Medicine  •  2015  |  View Paper
Our results reveal that melatonin produces a potent hepatoprotective mechanism against CP.
Therefore, melatonin could be a potent candidate to use concomitantly as a supplement agent against hepatotoxicity of CP for the patients undergoing chemotherapy.
BioMed research international  •  2014  |  View Paper
The number (mean ± SE) of chromosomal … in pinealectomized (PINX) animals treated with melatonin … CP (2.50 ± 0.50/100 cells) was lower than that obtained for PINX animals injected with CP (12 ± 1.8/100 cells), thus showing a reduction of 85.8% in the number of chromosomal aberrations.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas  •  2013  |  View Paper
CP injection resulted in severe cystitis with increase in voiding behaviors, histological damage, mast cell proliferation, SP, and proinflammatory cytokine expression, which were significantly downregulated by melatonin pretreatment.
Inflammation  •  2012  |  View Paper
However, cleft palate, spina bifida and exencephalyincidence were 62.5%, 45.83% and 4.16% range in the group which received CP plus melatonin (10mg/kg), respectively.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft  •  2011  |  View Paper
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