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Last Updated: 2 months ago

Possible Interaction: Cyclophosphamide and Hesperidin

Research Papers that Mention the Interaction

Administration of hesperidin reduced the leukopenia induced by cyclophosphamide in normal mice.
Coadministration of hesperidin with cyclophosphamide in colon carcinoma (CT-26)–bearing mice was found to significantly inhibit cyclophosphamide-induced tumor growth delay.
These results imply that fruits containing hesperidin , such as citrus, might have side effects on the efficacy of cyclophosphamide in the treatment of patients with colon cancer.
These results show that hesperidin interacts with cyclophosphamide to inhibit its antitumor effect.
Integrative cancer therapies  •  2012  |  View Paper
It is obvious that hesperidin , may with antioxidative activity, reduced the oxidative stress and genotoxicity induced by cyclophosphamide in mouse bone marrow cells.
Three last doses of hesperidin significantly reduced frequency of MnPCEs induced by cyclophosphamide (p<0.0001).
Archives of pharmacal research  •  2008  |  View Paper
In addition, HSN significantly prevented the histopathological injury, and kidney injury molecule-1 expression in kidneys of mice given CPE.
It was concluded that HSN guarded against nephrotoxic effect of CPE in mice by tackling oxidative/nitrative stress, inflammation, and apoptosis.
Drug and chemical toxicology  •  2019  |  View Paper