Possible Interaction: Cyclophosphamide and Hesperidin

“Administration of hesperidin reduced the leukopenia induced by cyclophosphamide in normal mice.”

“Coadministration of hesperidin with cyclophosphamide in colon carcinoma (CT-26)–bearing mice was found to significantly inhibit cyclophosphamide-induced tumor growth delay.”

“These results imply that fruits containing hesperidin , such as citrus, might have side effects on the efficacy of cyclophosphamide in the treatment of patients with colon cancer.”

“These results show that hesperidin interacts with cyclophosphamide to inhibit its antitumor effect.”

“It is obvious that hesperidin , may with antioxidative activity, reduced the oxidative stress and genotoxicity induced by cyclophosphamide in mouse bone marrow cells.”

“Three last doses of hesperidin significantly reduced frequency of MnPCEs induced by cyclophosphamide (p<0.0001).”

“Conclusion: Our study demonstrated that myricetin, apigenin, and hesperidin can reduce the immunosuppressive effect of cyclophosphamide by enhancing both innate and adaptive immune responses, and these compounds may be useful immunomodulatory agents during cancer chemotherapy.”

“In addition, HSN significantly prevented the histopathological injury, and kidney injury molecule-1 expression in kidneys of mice given CPE.”

“It was concluded that HSN guarded against nephrotoxic effect of CPE in mice by tackling oxidative/nitrative stress, inflammation, and apoptosis.”