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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclophosphamide
supplement:
Glutathione
Research Papers that Mention the Interaction
“In cardiac tissues, 3-day doses of CP resulted in significantly higher heart weight, cardiac troponin I, myeloperoxidase, malondialdehyde, hydrogen peroxide and lower superoxide dismutase, catalase, glutathione peroxidase activities, and reduced glutathione levels.”
Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats“ Cyclophosphamide transiently decreased nude rat white blood cell counts and glutathione concentration, whereas serum vascular endothelial growth factor was significantly elevated.”
“…,glutathione plays a role in the detoxification and repair of … injury by such diverse agents as mechlorethamine, melphalan, cyclophosphamide , nitrosoureas, 6-thiopurine, 4'-(9-acridinylamino)methanesulfon-m-anisidide, the quinone antibiotics (including Adriamycin, daunorubicin, … mitomycin C), the sesquiterpene lactones (such as vernolepin), and other sulfhydryl-reactive diterpenes (like jatrophone).”
“In addition, CYP and MTX were significantly induced ROS formation, MMP collapse, lysosomal membrane damage, lipid peroxidation, and GSH depletion compared with the controls.”
“PAC-1A and CP synergistically increased cytotoxicity and expression of pro-apoptotic markers, reduced cellular glutathione ( GSH ) and superoxide dismutase (SOD) levels.”
“The findings illustrated that CP induces atypical appearance in tissue structure, disorder of sperm parameters dysfunction, decrease of testosterone, oxidative stress (an increase of MDA and decrease of GSH ), apoptosis and inflammation in testicular tissue.”
Protective effects of sinapic acid against cyclophosphamide‐induced testicular toxicity via inhibiting oxidative stress, caspase‐3 and NF‐kB activity in BALB/c mice“KEY FINDINGS CY si gnificantly depressed bladder activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH ) l evels, whereas malondialdehyde level was increased prominently.”
“As compared with the control group, CP increased the levels of MDA, NOx, IL-10, TNF-α, FSH, LH, and collagen area fraction; however, levels of GSH , SOD, VEGF, AMH, estrogen, and PCNA immunoexpression were reduced with CP.”
“ CP also markedly inhibited the activities of superoxide dismutase (SOD), catalase (CAT), and reduced glutahione ( GSH ) and increased malondialdehyde (MDA) content.”
“ CP also markedly inhibited the activities of SOD, CAT, and GSH and increased MDA content.”
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