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Last Updated: 4 months ago

Possible Interaction: Cyclophosphamide and Glutathione

Research Papers that Mention the Interaction

PAC-1A and CP synergistically increased cytotoxicity and expression of pro-apoptotic markers, reduced cellular glutathione ( GSH ) and superoxide dismutase (SOD) levels.
International journal of oncology  •  2011  |  View Paper
Moreover, CP also significantly increased the lipid peroxidation as evidenced by an increase in the MDA content and decreased the antioxidant enzyme ( GSH ) in mice liver.
Pharmacognosy research  •  2015  |  View Paper
Development of resistance of cancer cells against cyclophosphamide (CP) is probably associated with an increased conjugation with glutathione.
Chemico-biological interactions  •  1994  |  View Paper
In cardiac tissues, 3-day doses of CP resulted in significantly higher heart weight, cardiac troponin I, myeloperoxidase, malondialdehyde, hydrogen peroxide and lower superoxide dismutase, catalase, glutathione peroxidase activities, and reduced glutathione levels.
Journal of evidence-based integrative medicine  •  2018  |  View Paper
Cyclophosphamide transiently decreased nude rat white blood cell counts and glutathione concentration , whereas serum vascular endothelial growth factor was significantly elevated.
Neoplasia  •  2009  |  View Paper
…,glutathione plays a role in the detoxification and repair of … injury by such diverse agents as mechlorethamine, melphalan, cyclophosphamide , nitrosoureas, 6-thiopurine, 4'-(9-acridinylamino)methanesulfon-m-anisidide, the quinone antibiotics (including Adriamycin, daunorubicin, … mitomycin C), the sesquiterpene lactones (such as vernolepin), and other sulfhydryl-reactive diterpenes (like jatrophone).
Cancer research  •  1984  |  View Paper
CP also markedly inhibited the activities of superoxide dismutase (SOD), catalase (CAT), and reduced glutahione ( GSH ) and increased malondialdehyde (MDA) content.
Drug and chemical toxicology  •  2013  |  View Paper
CP also markedly inhibited the activities of SOD, CAT, and GSH and increased MDA content.
Drug and chemical toxicology  •  2013  |  View Paper
The dose-related cardiotoxicity of CPA is associated with a rapid decrease in cardiac glutathione ( GSH ) and oxidative cardiac injury.
Nutrition  •  2009  |  View Paper
Also, GSH , GSH-Px, and SOD enzyme activities were significantly increased in the cyclophosphamide and 5-fluorouracil groups, compared to the other two antineoplastic agent groups (P < 0.01).
Microsurgery  •  2006  |  View Paper
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