Possible Interaction: Cyclophosphamide and Ginseng

“The … that ginseng stem-leaf … inhibited cyclophosphamide-induced oxidative stress by increasing the organ indices, total antioxidant capacity, and the levels of glutathione, ascorbic acid, and α-tocopherol, while … the activity of total superoxide dismutase, catalase, and glutathione peroxidase, as well as decreasing the protein carbonyl content and malondialdehyde.”

“Metabolomics study revealed that 33 endogenous metabolites were changed by CP , 19 of which were reversed when ginseng was co-administrated via two main pathways, i.e., GSH metabolism and primary bile acids synthesis.”

“The bioginseng exerted an antimutagenic effect with respect to nitrosomethylurea and cyclophosphamide.”

“An extract of Ginseng radix showed protective effects on the number and functions of macrophages by treatment with CY but did not show any effects on the lymphocytic blastogenesis.”

“We found that Ginseng radix , Lithospermi radix, Astragli radix and Glycyrrhizae radix somewhat reduced suppression of cytokine production in CY treated macrophages.”

“Therefore, according to the results of this study, co-administration of CP and American ginseng can improve these parameters.”