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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclophosphamide
supplement:
Cysteine
Research Papers that Mention the Interaction
“The administration of thiol compounds (glutathione or cysteine ) decreased the teratogenicity of cyclophosphamide , whereas the administration of a thiol-depleting agent (diethyl maleate) increased its teratogenicity.”
Modification of the teratogenicity and mutagenicity of cyclophosphamide with thiol compounds.“These effects of CP (or acrolein) were enhanced by diethyl maleate but partially blocked by cysteine.”
“The denaturation produced by CP metabolites could be blocked by cysteine , suggesting an interaction between CP metabolite(s) and sulfhydryl groups in cysteine and probably in cytochrome P-450.”
“ Cysteine strongly inhibited the ability of cyclophosphamide and nitrogen mustard to depress the direct plaque-forming cell response of mice to sheep red cells.”
“The fluorescence emission of CPM surges when it forms a covalent bond with the side chain of a free Cys , which becomes more readily accessible upon protein thermal denaturation.”
Cysteine residue is not essential for CPM protein thermal-stability assay
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