“ CA in combination with VBL and CP induced a higher percentage of apoptosis than single agents in both cell lines.”
“ CA showed synergistic cytotoxic effects with vinblastine (VBL) and cyclophosphamide (CP) as indicated by the combination index values of <1 for VBL + CA, CP + CA, and VBL + CP + CA combinations in both embryonal and alveolar rhabdomyosarcomas.”
“When lower doses of CA (0.1–0.2 µg/ml) were combined with cancer drugs like CP and VBL, caspase‐3 activity increased significantly compared with individual agents and correlated with the percentage of apoptotic cells.”