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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclophosphamide
supplement:
Apigenin
Research Papers that Mention the Interaction
“The treatment of apigenin results in a significant, dose dependent decrease in the genotoxic damage, induced by mitomycin C and cyclophosphamide.”
Antigenotoxic effect of apigenin against anti-cancerous drugs.“In vivo, apigenin caused a statistically significant decrease in micronucleus frequency in response to cyclophosphamide , possibly due to active flavonoid metabolite formation or inhibition of cyclophosphamide metabolic activation.”
The effect of apigenin on cyclophosphamide and doxorubicin genotoxicity in vitro and in vivo“Conclusion: Our study demonstrated that myricetin, apigenin , and hesperidin can reduce the immunosuppressive effect of cyclophosphamide by enhancing both innate and adaptive immune responses, and these compounds may be useful immunomodulatory agents during cancer chemotherapy.”
Protective effect of myricetin, apigenin, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression
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