Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Cyclandelate and Calcium Supplement

Research Papers that Mention the Interaction

Cyclandelate may affect the influx of calcium ions in cells and act as a calcium overload blocker.
Drugs  •  1987  |  View Paper
In platelets stim- ulated with thrombin (5 U/ml) or platelet activating factor (1 jumol/L), cyclandelate strongly inhibited the increase of cystolic Ca++ in the presence of extracellular Ca++ , but in the absence of extracellular Ca++ only a weak inhibition was observed.
Thus, at concentrations which inhibit platelet aggregation, cyclandelate prevents the mobilisation of Ca++ ions induced by such agonists as thrombin and platelet activating factor.
Drugs  •  1987  |  View Paper
Thus in rabbits receiving cyclandelate the total cholesterol and calcium content of aorta was decreased by 45% and 69% of control values, respectively.
Atherosclerosis  •  1984  |  View Paper