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Last Updated: 3 months ago

Possible Interaction: Curcumin and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

microM curcumin, vitamin C (56 nM-5.6 microM) inhibited apoptosis of HL-60 cells; GSH at low concentration (1 microM) reduced apoptosis but had no effect … and NAC at 10 and 100 microM, respectively, enhanced apoptosis, but this effect was abolished at higher concentration (1 mM) of NAC.
Asian Pacific journal of cancer prevention : APJCP  •  2005  |  View Paper
Further studies showed that all water-soluble antioxidants ASA , NAC and GSH significantly enhanced both the antioxidant and the anticancer activity of low Cur.
Die Pharmazie  •  2005  |  View Paper
Interestingly, curcumin revealed synergistic antioxidant effect when combined with gallic acid whereas the antagonistic effect occurred in curcumin combination with ascorbic acid or xanthone.
These results suggest that curcumin-gallic acid combination is the potential antioxidant mixture to be used in place of the individual substance whereas using of curcumin in combination with ascorbic acid or xanthone should be avoid.
Drug discoveries & therapeutics  •  2015  |  View Paper
The association constant, Ka, that resulted between curcumin and ascorbic acid was calculated as 2.15 × 104 with the free energy of association, ∆Ga, of −24.71 kJ/mol.
The observed fluorescence intensity of curcumin was enhanced by introduction of ascorbic acid to the curcumin solution.
Journal of Fluorescence  •  2015  |  View Paper
In conclusion, the results demonstrated that the combined pretreatment with curcumin along with vitamin C could recover the alterations and offer more protection than curcumin or vitamin C alone against Cd hepatotoxicity.
The combined treatment with curcumin along with vitamin C before Cd intoxication was more effective than that with either of them alone in reducing such changes and reverse the changes almost similar to that of control.
The objective of the study was to investigate whether the combined pretreatment with curcumin and vitamin C offers more beneficial effects than that provided by either of them alone in reversing cadmium (Cd)- induced hepatotoxicity.
Journal of basic and clinical pharmacy  •  2012  |  View Paper
It can be concluded that AA in MS shielded the degradation of CUR.
Stabilisation of CUR in alkaline pH was successfully guarded by AA to the extent 98.5-100%.
Journal of microencapsulation  •  2018  |  View Paper
CONCLUSIONS The results of this study suggest that there could be an antagonistic bactericidal effect between AA and CUR and AA and BA as well as a synergistic bactericidal effect between BA and CUR.
CONCLUSIONS The results of this study suggest that there could be an antagonistic bactericidal effect between AA and CUR and AA and BA as well as a synergistic bactericidal effect between BA and CUR.
Journal of applied microbiology  •  2018  |  View Paper
METHODS AND RESULTS Here, we … gallic acid, ascorbate vitamin C ), tert-butylhydroquinone (TBHQ), …), dramatically increased curcumin stability in phosphate buffer at physiological pH. When treated in basal cell culture medium in MC38 colon … showed a weak antiproliferative effect; co-addition of antioxidants enhanced stability and antiproliferative effect of curcumin.
METHODS AND RESULTS Here, …, including gallic acid, ascorbate vitamin C ), tert-butylhydroquinone (TBHQ), …), dramatically increased curcumin stability in phosphate buffer at physiological pH. When treated in basal cell culture medium in MC38 colon … showed a weak antiproliferative effect; co-addition of antioxidants enhanced stability and antiproliferative effect of curcumin.
Molecular nutrition & food research  •  2016  |  View Paper
In conclusion, curcumin might increase the effect of vitamin C in protecting the function of endothelial cells through its anti-oxidant with hypoglycemic and hypolipidemic actions.
Clinical hemorheology and microcirculation  •  2006  |  View Paper
The stability of curcumin was strongly improved by lowering the pH or by adding glutathione (GSH), N-acetyl L-cysteine (NAC), ascorbic acid , rat liver microsomes, or rat liver cytosol.
Biochemical pharmacology  •  1996  |  View Paper