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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“… curcumin, vitamin C (56 nM-5.6 microM) inhibited apoptosis of HL-60 cells; GSH at low concentration (1 microM) reduced apoptosis but had no effect … Trolox and NAC at 10 and 100 microM, respectively, enhanced apoptosis, but this effect was abolished at higher concentration (1 mM) of NAC.”
Effects of water-soluble antioxidants and MAPKK/MEK inhibitor on curcumin-induced apoptosis in HL-60 human leukemic cells.“Further studies showed that all water-soluble antioxidants ASA , NAC and GSH significantly enhanced both the antioxidant and the anticancer activity of low Cur.”
“It can be concluded that AA in MS shielded the degradation of CUR.”
“Stabilisation of CUR in alkaline pH was successfully guarded by AA to the extent 98.5–100%.”
Colon targeted curcumin microspheres laden with ascorbic acid for bioavailability enhancement“In conclusion, curcumin might increase the effect of vitamin C in protecting the function of endothelial cells through its anti-oxidant with hypoglycemic and hypolipidemic actions.”
“The stability of curcumin was strongly improved by lowering the pH or by adding glutathione (GSH), N-acetyl L-cysteine (NAC), ascorbic acid , rat liver microsomes, or rat liver cytosol.”
“Synergy with vitC was observed with curcumin and quercetin.”
Synergy of the Inhibitory Action of Polyphenols Plus Vitamin C on Amyloid Fibril Formation: Case Study of Human Stefin B“In addition, curcumin only and/or co-treatment with ascorbic acid caused lipid peroxidation in S. aureus and E. coli, and by extension led to DNA damage, indicative of oxidative stress.”
“In summary, curcumin retention after storage declined in the following order: 82.6% (Trolox) ~82.2% ( ascorbic acid ) >79.5% (ascorbyl palmitate) ≫57.9% (control) >52.7% (α-tocopherol).”
“Interestingly, curcumin revealed synergistic antioxidant effect when combined with gallic acid whereas the antagonistic effect occurred in curcumin combination with ascorbic acid or xanthone.”
“These results suggest that curcumin-gallic acid combination is the potential antioxidant mixture to be used in place of the individual substance whereas using of curcumin in combination with ascorbic acid or xanthone should be avoid.”
“The association constant, Ka, that resulted between curcumin and ascorbic acid was calculated as 2.15 × 104 with the free energy of association, ∆Ga, of −24.71 kJ/mol.”
“The observed fluorescence intensity of curcumin was enhanced by introduction of ascorbic acid to the curcumin solution.”
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