Possible Interaction: Curcumin and Tretinoin

“In addition, curcumin could concentration-dependently regulate genes associated with lipid and retinoid metabolism.”

“Although curcumin alone had little or no effect on cellular differentiation, when it was combined with all-trans retinoic acid or 1α,25-dihydroxyvitamin D3 a synergistic effect was observed.”

“Co-treatment of the cells with curcumin and RA results in increased apoptosis as demonstrated by elevated cleavage of poly(ADP-ribose) polymerase and cleaved caspase-9.”

“By targeting the … pathway, curcumin prevents … of retinoic acid to PPARβ/δ and suppresses retinoic acid-induced PPARβ/δ target gene, VEGF-A. Our data demonstrates that suppression of …/ PPARβ/δ pathway by curcumin sensitizes retinoic acid resistant triple negative breast cancer cells to retinoic acid mediated growth suppression.”

“The combination of curcumin with retinoic acid suppressed PPARβ/δ target genes, VEGF-A and PDK1.ConclusionsCurcumin suppresses the expression level of FABP5 and PPARβ/δ in triple negative mammary carcinoma cells.”

“ATRA could promote phosphorylation of AKT in NB4 cells at short time, but not had effect on phosphorylation of AKT in NB4-R1 cells; the curcumin could enhance the phosphorylation of AKT in NB4-1R cells, the curcumin combined with ATRA could further enhance the phosphorylation of AKT.”

“The results … that ATRA had no influence on NB4-R1 cell …, but enhanced the inhibitory effect of curcumin on NB4-R1 cell growth; the curcumin or ATRA alone did not affect NB4-R1 differentiation; … combined with ATRA could obviously induce CD11b expression; the cell morphology showed obvious differentiation characteristics.”

“However, CM along with several analogs elicited transcriptional activation in retinoic acid and retinoid X receptor (RXR) responsive systems.”

“ Curcumin , a JNK blocker, blocked the apoptosis and the growth inhibition induced by ATRA.”

“Combinations of RA and curcumin or vitamin D3 and curcumin inhibited the proliferation of HL-60 cells to a greater extent than was observed for either compound alone.”

“Combinations of curcumin and RA have a particularly potent inhibitory effect on the proliferation of HL-60 cells.”

“Studies on cell cycle … with a combination of RA … curcumin for 48 or 96 h reduced the proportion of cells in the S phase of the cell cycle and increased …/G1 phase of the cell cycle to a greater extent than occurred for cells treated with either compound alone.”

“Synergistic induction of differentiation as measured by the above markers was observed when 1-10 muM curcumin was combined with 10-100 nM all-trans retinoic acid (RA) or with 100 nM 1 alpha, 25-dihydroxyvitamin D3 (vitamin D3).”

“The results indicate that curcumin is a weak stimulator of differentiation in HL-60 cells and that is has synergistic effects when combined with RA or vitamin D3.”

“ Curcumin suppressed retinoic acid stimulated expression of ADAMTS-5, and both polyphenols suppressed basal expression of ADAMTS-5.”