Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Curcumin and Tretinoin

supplement:

Tretinoin

Research Papers that Mention the Interaction

Co-treatment of the cells with curcumin and RA results in increased apoptosis as demonstrated by elevated cleavage of poly(ADP-ribose) polymerase and cleaved caspase-9.
Oncology reports  •  2017  |  View Paper
RESULTS Curcumin was able to downregulate the expression of TG2 in human nervous cell lines, which was also the case after treatment with retinoic acid.
RESULTS Curcumin was able to downregulate the expression of TG2 in human nervous cell lines, which was also the case after treatment with retinoic acid.
Neuroimmunomodulation  •  2016  |  View Paper
By targeting the … pathway, curcumin prevents … of retinoic acid to PPARβ/δ and suppresses retinoic acid-induced PPARβ/δ target gene, VEGF-A. Our data demonstrates that suppression of …/ PPARβ/δ pathway by curcumin sensitizes retinoic acid resistant triple negative breast cancer cells to retinoic acid mediated growth suppression.
The combination of curcumin with retinoic acid suppressed PPARβ/δ target genes, VEGF-A and PDK1.ConclusionsCurcumin suppresses the expression level of FABP5 and PPARβ/δ in triple negative mammary carcinoma cells.
BMC Cancer  •  2014  |  View Paper
ATRA could promote phosphorylation of AKT in NB4 cells at short time, but not had effect on phosphorylation of AKT in NB4-R1 cells; the curcumin could enhance the phosphorylation of AKT in NB4-1R cells, the curcumin combined with ATRA could further enhance the phosphorylation of AKT.
The results … that ATRA had no influence on NB4-R1 cell …, but enhanced the inhibitory effect of curcumin on NB4-R1 cell growth; the curcumin or ATRA alone did not affect NB4-R1 differentiation; … combined with ATRA could obviously induce CD11b expression; the cell morphology showed obvious differentiation characteristics.
Zhongguo shi yan xue ye xue za zhi  •  2013  |  View Paper
However, CM along with several analogs elicited transcriptional activation in retinoic acid and retinoid X receptor (RXR) responsive systems.
Bioorganic & medicinal chemistry  •  2013  |  View Paper
Curcumin , a JNK blocker, blocked the apoptosis and the growth inhibition induced by ATRA.
Zhonghua zhong liu za zhi [Chinese journal of oncology]  •  2003  |  View Paper
Combinations of RA and curcumin or vitamin D3 and curcumin inhibited the proliferation of HL-60 cells to a greater extent than was observed for either compound alone.
Combinations of curcumin and RA have a particularly potent inhibitory effect on the proliferation of HL-60 cells.
Studies on cell cycle … with a combination of RA … curcumin for 48 or 96 h reduced the proportion of cells in the S phase of the cell cycle and increased …/G1 phase of the cell cycle to a greater extent than occurred for cells treated with either compound alone.
Synergistic induction of differentiation as measured by the above markers was observed when 1-10 muM curcumin was combined with 10-100 nM all-trans retinoic acid ( RA ) or with 100 nM 1 alpha, 25-dihydroxyvitamin D3 (vitamin D3).
The results indicate that curcumin is a weak stimulator of differentiation in HL-60 cells and that is has synergistic effects when combined with RA or vitamin D3.
Oncology research  •  1997  |  View Paper
Although curcumin alone had little or no effect on cellular differentiation, when it was combined with all-trans retinoic acid or 1alpha,25-dihydroxyvitamin D3 a synergistic effect was observed.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1997  |  View Paper
Curcumin suppressed retinoic acid stimulated expression of ADAMTS-5, and both polyphenols suppressed basal expression of ADAMTS-5.
The Journal of nutritional biochemistry  •  2012  |  View Paper