Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Curcumin and Serum Albumin, Human

Research Papers that Mention the Interaction

Our results indicated that AFM1 and Pb ions promote the fibrillation of HSA and accelerate ROS production, which were inhibited in the presence of curcumin.
The monitoring of the changes in reactive oxygen species (ROS) levels upon incubation of curcumin with HSA showed a significant decrease in ROS levels.
Protein and peptide letters  •  2015  |  View Paper
Conclusion drawn from our study demonstrates that curcumin interacts with HSA strongly thereby its poor half life is due to high rate of its metabolic detoxification as reported in literature.
Journal of Molecular Modeling  •  2014  |  View Paper
In the presence of both transferrin and IgG, curcumin continues to undergo rapid hydrolysis but this reaction is suppressed by the presence of either HSA or fibrinogen with an impressive yield of approximately 95%.
Therefore, strong interactions with HSA and fibrinogen inhibit hydrolysis of curcumin and in turn lead to effective suppression of degradation.
Langmuir : the ACS journal of surfaces and colloids  •  2009  |  View Paper
Binding of curcumin to HSA induces an extrinsic CD band in the visible region.
Thus, HSA has two kinds of affinity sites for curcumin , one with high affinity and the other with lower affinity.
Lipids  •  1999  |  View Paper
We found that the fluorescence intensity of curcumin CU ) can be highly enhanced by protein bovine serum albumin (BSA) and human serum albumin (HSA) in the presence of chitosan (CTS).
Journal of Fluorescence  •  2011  |  View Paper