Possible Interaction: Curcumin and Serum Albumin, Human

“The color changes of curcumin embedded in …) due to the inhibitory effect of HSA … curcumin degradation in alkaline solutions, which can be monitored visually (naked eye/Smartphone camera) or spectroscopically using a … proportional to the HSA concentration in the range of 10-300 μM and 25-400 μM, respectively.”

“CDs and PF-127 seem to decrease Cur binding to HSA , probably through competitive binding.”

“Our results indicated that AFM1 and Pb ions promote the fibrillation of HSA and accelerate ROS production, which were inhibited in the presence of curcumin.”

“The monitoring of the changes in reactive oxygen species (ROS) levels upon incubation of curcumin with HSA showed a significant decrease in ROS levels.”

“Conclusion drawn from our study demonstrates that curcumin interacts with HSA strongly thereby its poor half life is due to high rate of its metabolic detoxification as reported in literature.”

“In the presence of both transferrin and IgG, curcumin continues to undergo rapid hydrolysis but this reaction is suppressed by the presence of either HSA or fibrinogen with an impressive yield of approximately 95%.”

“Therefore, strong interactions with HSA and fibrinogen inhibit hydrolysis of curcumin and in turn lead to effective suppression of degradation.”

“Binding of curcumin to HSA induces an extrinsic CD band in the visible region.”

“Thus, HSA has two kinds of affinity sites for curcumin , one with high affinity and the other with lower affinity.”

“The fluorimetric results revealed that Zr(CUR) and CUR could effectively quench the endogenous fluorescence of HSA , formed a 1:1 complex, with a static quenching mechanism.”