Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Curcumin and Serine

supplement:

Serine

Research Papers that Mention the Interaction

The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas  •  2005  |  View Paper
Replacing the 195 cysteine residue with serine (C195S) reversed the effect of CAPE from inhibition to facilitation and significantly weakened the inhibitory effect of curcumin.
Biochemical and biophysical research communications  •  2012  |  View Paper
Curcumin upregulated the expression of p53 as well as its phosphorylation at serine 15 , and acetylation in a concentration-dependent manner.
Furthermore, curcumin inhibited expression of phosphatidyl-inositol-3 kinase (PI3K) p110 and p85 subunits, and phosphorylation of Ser 473 AKT/PKB.
International journal of oncology  •  2007  |  View Paper
The growth-inhibitory effect of curcumin was accompanied by decreased expression of cyclin D3 and ser 780 phosphorylation of retinoblastoma protein.
Endocrinology  •  2008  |  View Paper