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Last Updated: 3 months ago

Possible Interaction: Curcumin and Serine



Research Papers that Mention the Interaction

We found that this effect correlated with the prevention of the accumulation in S and G2/M phase of cell cycle induced by curcumin.
Molecular carcinogenesis  •  2015  |  View Paper
Replacing the 195 cysteine residue with serine (C195S) reversed the effect of CAPE from inhibition to facilitation and significantly weakened the inhibitory effect of curcumin.
Biochemical and biophysical research communications  •  2012  |  View Paper
Curcuminoids also promote the phosphorylation of p53 on serine 15 in a dose-dependent and p38-dependent manner, suggesting that these compounds may activate p53.
Experimental dermatology  •  2010  |  View Paper
Curcumin upregulated the expression of p53 as well as its phosphorylation at serine 15 , and acetylation in a concentration-dependent manner.
International journal of oncology  •  2007  |  View Paper
Curcumin can inhibit Lovo cells growth and the cellular mechanism responsible for the action is to arrest the cell cycle in S , G2/M phase and to induce apoptotic cell death.
Anticancer research  •  1999  |  View Paper
These results demonstrated that the expression of proteins involved in the S to M phase transition in transgenic mice is suppressed by curcumin.
Molecular nutrition & food research  •  2011  |  View Paper
The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas  •  2005  |  View Paper
Thus, the data suggest that curcumin can inhibit differentiation, promote cell survival and inhibit cell cycle progression from G1 to S in NSCs, and that these effects are mediated through the regulation of Atg7 and p62.
International journal of molecular medicine  •  2018  |  View Paper