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Last Updated: 3 months ago

Possible Interaction: Curcumin and Resveratrol



Research Papers that Mention the Interaction

Combination of curcumin with therapeutic cancer agents like tolfenamic acid, 5-fluorouracil, resveratrol and dasatinib showed improved cytotoxicity and chemotherapeutic effect.
Life sciences  •  2019  |  View Paper
Through FACS analysis and activated caspase-3 labeling we demonstrate that CUR induces apoptosis of rabdomyosarcoma and osteosarcoma cells and that this effect is potentiated when CUR is combined with RES or DADS.
Frontiers in bioscience  •  2012  |  View Paper
Our findings indicated that the combination of resveratrol and curcumin increased growth performance, enhanced intestine function, and protected piglet health, which may be associated with changes in m6A methylation and gene expression, suggesting that curcumin and resveratrol may be a potential natural alternative to antibiotics.
The results showed that the combination of resveratrol and curcumin improved growth performance and enhanced intestinal mucosal integrity and functions in weaning piglets.
We hypothesized that the combination of resveratrol and curcumin could affect growth performance, intestinal mucosal integrity, m6A RNA methylation, and gene expression in weaning piglets.
ACS omega  •  2019  |  View Paper
Our present study in isolated testicular germ cell population from adult male Wistar rats, highlighted the synergistic protective effect of curcumin and resveratrol against B(a)P induced p53 mediated germ cell apoptosis.
Front. Pharmacol.  •  2016  |  View Paper
In this study, we investigated whether curcumin and resveratrol can synergistically inhibit the catabolic effects of IL-1β, specifically the inhibition of the MAPK and subsequent apoptosis in human articular chondrocytes.
Genes & Nutrition  •  2010  |  View Paper
Curcumin and resveratrol together (5 microM each) resulted in a synergistic antioxidant effect: 15.5 +/- 1.7% greater than an average of individual activities.
In relation to two other well-known antioxidants, curcumin shows significantly greater synergism with resveratrol than with quercetin.
Phytotherapy research : PTR  •  2009  |  View Paper
After oral administration to rabbits, the self-microemulsifying formulation containing curcumin together with resveratrol increased the total plasma concentrations of curcumin and resveratrol by 10-fold and 6-fold, respectively, compared to the unformulated combination.
The use of curcumin and resveratrol in combination has now become increasingly of interest because of their synergistic effects as therapeutic agents for various diseases, especially cancer.
curcumin … resveratrol showed greater antioxidant activity than that of the formulations with individual compounds, while the cytotoxic activity against HT-29 of the co-formulation (IC50 = … the ratio 1 : 1) was less than the formulation with only curcumin (IC50 = 30.1 µM) and only resveratrol (IC50 = 25.4 µM).
Planta medica  •  2016  |  View Paper
Blocking this ERK1/2-mediated temozolomide and curcumin induced autophagy with resveratrol , a blood-brain barrier permeable drug, improved temozolomide/curcumin efficacy in brain-implanted tumors.
Cancer letters  •  2015  |  View Paper
ConclusionsThese results suggest that curcumin alters the phase II distribution of resveratrol through inhibiting efflux transporters including MRP2 and BCRP.
Pharmaceutical Research  •  2015  |  View Paper
Approximately, ten fold lower IC50 value was noted in cells treated with the combination of resveratrol (3μM) and curcumin (3μM) in comparison to 30μM of resveratrol or curcumin alone.
Resveratrol exposure increased the intracellular uptake of curcumin in a dose dependent manner and caused apoptosis in MCF-10A-Tr cells.
Thus, our findings revealed resveratrol and curcumin synergistically caused apoptosis in cigarette smoke induced breast cancer cells through p2(Waf/Cip1) mediated inhibition of Hedgehog-Gli cascade.
The international journal of biochemistry & cell biology  •  2015  |  View Paper
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