Possible Interaction: Curcumin and Quercetin

“Interestingly, separate … supplementation of curcumin (60 mg/…) and quercetin (40 mg/kg body weight) to BP-treated animals resulted in a significant decrease in the protein expression of Bcl-… a significant increase in the protein expression of Bax along with a noticeable improvement in the number of apoptotic cells.”

“Therefore, curcumin and quercetin , if given in combination shall exhibit enhanced chemopreventive potential against development of lung carcinogenesis by stimulating the apoptotic machinery.”

“The in vivo pharmacokinetics of curcumin showed obvious changes when it was coadministered with quercetin , with the significantly lower plasma concentration and greater biliary excretion of curcumin and curcumin sulfate.”

“The present study suggests that quercetin could enhance the cellular uptake of curcumin and modulate in vivo pharmacokinetics of curcumin, and it could be related to albumin-binding interaction.”

“We found that quercetin inhibited the binding of curcumin to albumin and increased the uptake of curcumin into WiDr cells, the human colon carcinoma cell.”

“In conclusion, it was seen that curcumin is the much better inhibitor than quercetin and resveratrol for hGR according to both in vitro and in silico studies.”

“At 1.5 μmol/L curcumin , pHer2 and Her2 (but not pAkt) were reduced, with all three pathway markers reduced more in the presence of quercetin.”

“At 4 μmol/L, curcumin reduced Her2 signaling, and even more when combined with quercetin or OptiBerry.”

“Incubation with Curcumin and Quercetin decreased the EGFR levels.”

“Further, a synergistic action of quercetin and curcumin was observed in modulating the BRCA1 level and in inhibiting the cell survival and migration of TNBC cell lines.”

“Furthermore, BRCA1 knockdown induced cell survival and cell migration in ER + cells were significantly decreased by the combined treatment of quercetin and curcumin.”

“Our present study concluded that the combination treatment of quercetin and curcumin acts synergistically to induce anticancer activity against TNBC cells by modulating tumor suppressor genes.”

“The use of quercetin and curcumin combination potentiates individual apoptotic effects of the polyphenols and reduces their effective dose thereby preventing potential toxic effects on normal cells.”

“We have observed that quercetin and curcumin combination induced apoptosis accompanied by increased ROS and decreased GSH levels as well as loss of mitochondrial membrane potential.”

“Combined treatment with curcumin and quercetin resulted in significant inhibition of cell proliferation, accompanied by loss of mitochondrial membrane potential (ΔΨm), release of cytochrome c and decreased phosphorylation of AKT and ERK.”

“Notably, effect of combined treatment with curcumin and quercetin on gastric cancer MGC-803 cells is stronger than that of individual treatment, indicating that curcumin and quercetin combinations have potential as anti-gastric cancer drugs for further development.”

“These results indicate that the combination of curcumin and quercetin induces apoptosis through the mitochondrial pathway.”

“Therefore, we hypothesize that curcumin and quercetin , both natural polyphenolic flavonoids, can "additively and synergistically" improve the physiological outcome after traumatic SCI when used in combination and termed 'Cur(Que)min' - thereby decreasing the dose levels and hence reducing the inherent high dose-cytotoxicity of the individual neuroactives.”

“Results of enzyme kinetics revealed that curcumin , compared to the polyphenols quercetin , myricetin, kaempferol, luteolin and rutin, elicited a stronger competitive inhibitory effect on Glo1 (Ki = 5.1±1.4 µM).”