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Last Updated: 3 months ago

Possible Interaction: Curcumin and Quercetin

supplement:

Quercetin

Research Papers that Mention the Interaction

CONCLUSIONS The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas in patients with FAP without appreciable toxicity.
CONCLUSIONS The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas in patients with FAP without appreciable toxicity.
RESULTS All 5 patients had a decreased polyp number and size from baseline after a mean of 6 months of treatment with curcumin and quercetin.
RESULTS All 5 patients had a decreased polyp number and size from baseline after a mean of 6 months of treatment with curcumin and quercetin.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association  •  2006  |  View Paper
CONCLUSION These results demonstrate that curcumin and quercetin inhibit cancer cell proliferation synergistically and Wnt/β-catenin signaling and apoptotic pathways are partly responsible for antiproliferative activities.
CONCLUSION These results demonstrate that curcumin and quercetin inhibit cancer cell proliferation synergistically and Wnt/β-catenin signaling and apoptotic pathways are partly responsible for antiproliferative activities.
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2019  |  View Paper
The use of quercetin and curcumin combination potentiates individual apoptotic effects of the polyphenols and reduces their effective dose thereby preventing potential toxic effects on normal cells.
We have observed that quercetin and curcumin combination induced apoptosis accompanied by increased ROS and decreased GSH levels as well as loss of mitochondrial membrane potential.
Nutrition and cancer  •  2018  |  View Paper
Combined treatment with curcumin and quercetin resulted in significant inhibition of cell proliferation, accompanied by loss of mitochondrial membrane potential (ΔΨm), release of cytochrome c and decreased phosphorylation of AKT and ERK.
Notably, effect of combined treatment with curcumin and quercetin on gastric cancer MGC-803 cells is stronger than that of individual treatment, indicating that curcumin and quercetin combinations have potential as anti-gastric cancer drugs for further development.
These results indicate that the combination of curcumin and quercetin induces apoptosis through the mitochondrial pathway.
Molecules  •  2015  |  View Paper
Therefore, we hypothesize that curcumin and quercetin , both natural polyphenolic flavonoids, can "additively and synergistically" improve the physiological outcome after traumatic SCI when used in combination and termed 'Cur(Que)min' - thereby decreasing the dose levels and hence reducing the inherent high dose-cytotoxicity of the individual neuroactives.
Medical hypotheses  •  2014  |  View Paper
…)Quercetin has a higher … potential compared with curcumin at three different pH settings and is comparable to Trolox at pH 7-9.5; 2) its TAC is 3.5 … higher than curcumin; 3) it reduced LPS-induced ROS to near normal levels; 4) it reduced LPS-induced NO production.
…)Quercetin has a higher … potential compared with curcumin at three different pH settings and is comparable to Trolox at pH 7-9.5; 2) its TAC is 3.5 … higher than curcumin; 3) it reduced LPS-induced ROS to near normal levels; 4) it reduced LPS-induced NO production.
Advances in experimental medicine and biology  •  2011  |  View Paper
Results of enzyme kinetics revealed that curcumin , compared to the polyphenols quercetin , myricetin, kaempferol, luteolin and rutin, elicited a stronger competitive inhibitory effect on Glo1 (K(i) = 5.1+/-1.4 microM).
PloS one  •  2008  |  View Paper
CUR and QUER did not affect NQO1 activity, but the combined action caused an increase in the HO-1 activity without affecting the expression of the corresponding gene (Hmox1) and Nrf2 gene.
Membrane stabilizing action of CUR and QUER was also strongly expressed under its combined intake.
QUER , especially in combination with CUR , increased the AOA of blood plasma and reduced the content of lipid hydroperoxides in it.
The inducing effect of CUR and QUER on the activity of CYP450 enzymes greatly enhanced by their combined action.
Thus, we can conclude that CUR and QUER , especially in combination, contribute to the protective and adaptive capacity.
Voprosy pitaniia  •  2017  |  View Paper
Furthermore, BP treatment revealed alterations in lung histoarchitecture, which, however, were improved appreciably following combined supplementation with curcumin and quercetin.
Oncology letters  •  2016  |  View Paper
Mouse liver microsome studies showed that silibinin and quercetin inhibited curcumin glucuronidation effectively.
Drug Delivery and Translational Research  •  2014  |  View Paper
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