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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Curcumin and Phosphatidylserine

Research Papers that Mention the Interaction

The … curcumin inhibited the gastrointestinal carcinoma cell growth in a dose-dependent manner and cytotoxicity was more towards the gastric … and colon carcinoma cell HT-29 compared to normal gastric cell GES-1, and increased externalization of phosphatidylserine residue was observed by Annexin V/… in the two cell lines.
Apoptosis  •  2013  |  View Paper
It is noteworthy that coadministration of curcumin further significantly increased TATT-induced cytotoxicity, externalization of phosphatidylserine (representing early apoptosis), and the percentages of cells at the sub-G1 phase (representing late apoptosis), producing an additivity and/or synergistic effect, and vice versa.
Cell Biochemistry and Biophysics  •  2013  |  View Paper
Curcumin modulates the activity of protein kinase Cα (PKCα) when assayed in the presence of vesicles including phosphatidylcholine, phosphatidylserine and diacylglycerol.
Archives of biochemistry and biophysics  •  2011  |  View Paper
Furthermore, PS and curcumin in combination exerted a synergistic effect in down-regulating IL-1β release.
These results suggest that the association of PS with curcumin could be of potential therapeutic utility against diseases associated with microglial activation.
CNS & neurological disorders drug targets  •  2014  |  View Paper
Incubation of Leishmania promastigotes with curcumin caused exposure of phosphatidylserine to the outer leaflet of plasma membrane.
Apoptosis  •  2008  |  View Paper
Curcumin also inhibited PKC activity in vitro by competing with phosphatidylserine.
Journal of cellular biochemistry. Supplement  •  1997  |  View Paper