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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Curcumin
supplement:
Phenethyl Isothiocyanate
Research Papers that Mention the Interaction
“ PEITC and curcumin additively inhibited NF-kappaB luciferase activity.”
“We found an additive effect of PEITC and curcumin for the induction of apoptosis.”
Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.“Nrf2+/+ macrophages treated with PEITC and CUR exhibited a significant decrease in the expression of these anti-inflammatory genes along with an increase in the expression of hemeoxygenase-1 (HO-1), which is an antioxidative stress gene downstream of the Nrf2 transcription factor battery.”
Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin“Next, we evaluated the cancer-therapeutic potential of curcumin and PEITC in mice with well-established tumors, and the results showed that PEITC or curcumin alone had little effect, whereas combination of curcumin and PEITC significantly reduced the growth of PC-3 xenografts.”
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