Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Curcumin and Manganese

supplement:

Manganese

Research Papers that Mention the Interaction

The results provide a scientific basis that curcumin could significantly alleviate the development of MN by inducing autophagy and alleviating renal oxidative stress through the PI3K/AKT/mTOR and Nrf2/HO-1 pathways.
BioMed research international  •  2020  |  View Paper
Curcumin (0.1-10 µM) dose-dependently prevented Mn (250 µM)-induced cell death.
In addition, curcumin significantly increased intracellular glutathione (GSH) and moderately potentiated superoxide dismutase (SOD), both which were diminished by Mn treatment.
Biological & pharmaceutical bulletin  •  2017  |  View Paper
Moreover, the association of Mn plus curcumin significantly increased the levels of Mn and iron, and decreased the levels of dopamine and serotonin in the hippocampus.
Biological Trace Element Research  •  2014  |  View Paper
The treatment with Mn‐curcumin increased the Fe and Mn content in the kidneys of both control and Cd‐treated mice and Fe and Cu content in the brain of control mice.
Journal of applied toxicology : JAT  •  2006  |  View Paper